棘阿米巴微管蛋白对所有主要抗微管蛋白化合物类别的抗性的分子基础。
Molecular basis for resistance of acanthamoeba tubulins to all major classes of antitubulin compounds.
作者信息
Henriquez Fiona L, Ingram Paul R, Muench Stephen P, Rice David W, Roberts Craig W
机构信息
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, United Kingdom.
出版信息
Antimicrob Agents Chemother. 2008 Mar;52(3):1133-5. doi: 10.1128/AAC.00355-07. Epub 2007 Dec 10.
Abstract
Tubulin is essential to eukaryotic cells and is targeted by several antineoplastics, herbicides, and antimicrobials. We demonstrate that Acanthamoeba spp. are resistant to five antimicrotubule compounds, unlike any other eukaryote studied so far. Resistance correlates with critical amino acid differences within the inhibitor binding sites of the tubulin heterodimers.
摘要
微管蛋白对真核细胞至关重要，并且是多种抗肿瘤药、除草剂和抗菌剂的作用靶点。我们证明，棘阿米巴属对五种抗微管化合物具有抗性，这与迄今为止所研究的任何其他真核生物不同。抗性与微管蛋白异二聚体抑制剂结合位点内的关键氨基酸差异相关。
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