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微管蛋白作为一种抗原生动物药物靶点。

Tubulin as an antiprotozoal drug target.

作者信息

Werbovetz Karl A

机构信息

Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Ohio State University, 332 Lloyd M Parks Hall, 500 West 12th Avenue, Columbus, OH 43210, USA.

出版信息

Mini Rev Med Chem. 2002 Dec;2(6):519-29. doi: 10.2174/1389557023405648.

DOI:10.2174/1389557023405648
PMID:12370037
Abstract

Since tubulin is a known anticancer and anthelmintic drug target, the investigation of protozoal tubulin could lead to the development of new antiparasitic drugs. This review outlines the current state of knowledge concerning drug-mammalian tubulin interactions, the effects of antimicrotubule agents on parasites and parasite tubulin, and our current hypotheses regarding the development of selective ligands for protozoal tubulin as antiparasitic drug candidates.

摘要

由于微管蛋白是一种已知的抗癌和抗蠕虫药物靶点，对原生动物微管蛋白的研究可能会促成新型抗寄生虫药物的开发。本综述概述了关于药物与哺乳动物微管蛋白相互作用、抗微管药物对寄生虫和寄生虫微管蛋白的影响，以及我们目前关于开发原生动物微管蛋白选择性配体作为抗寄生虫药物候选物的假说等方面的现有知识状况。

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Mini Rev Med Chem. 2002 Dec;2(6):519-29. doi: 10.2174/1389557023405648.
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