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钙调神经磷酸酶抑制剂药物在体外与抗真菌药物协同作用，对抗新型隐球菌分离株：与实体器官移植受者隐球菌病的预后相关性。

Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: correlation with outcome in solid organ transplant recipients with cryptococcosis.

作者信息

Kontoyiannis Dimitrios P, Lewis Russell E, Alexander Barbara D, Lortholary Olivier, Dromer Françoise, Gupta Krishan L, John George T, Del Busto Ramon, Klintmalm Goran B, Somani Jyoti, Lyon G Marshall, Pursell Kenneth, Stosor Valentina, Munoz Patricia, Limaye Ajit P, Kalil Andre C, Pruett Timothy L, Garcia-Diaz Julia, Humar Atul, Houston Sally, House Andrew A, Wray Dannah, Orloff Susan, Dowdy Lorraine A, Fisher Robert A, Heitman Joseph, Albert Nathaniel D, Wagener Marilyn M, Singh Nina

机构信息

M. D. Anderson Cancer Center, University of Texas, Houston, Texas 77030-3930, USA.

出版信息

Antimicrob Agents Chemother. 2008 Feb;52(2):735-8. doi: 10.1128/AAC.00990-07. Epub 2007 Dec 10.

DOI:10.1128/AAC.00990-07
PMID:18070977
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2224743/
Abstract

Synergistic interactions were observed between CIs and antifungal agents against 53 (90%) of 59 Cryptococcus neoformans isolates from solid organ transplant recipients with cryptococcosis and may account for better outcomes in patients with cryptococcosis receiving these immunosuppressive agents.

摘要

在来自实体器官移植受者的59株新型隐球菌分离株中，观察到53株（90%）的隐球菌感染患者中，CI与抗真菌药物之间存在协同相互作用，这可能是接受这些免疫抑制剂的隐球菌感染患者预后较好的原因。

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本文引用的文献

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Immune reconstitution syndrome associated with opportunistic mycoses.与机会性真菌病相关的免疫重建综合征
Lancet Infect Dis. 2007 Jun;7(6):395-401. doi: 10.1016/S1473-3099(07)70085-3.
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Antifungal susceptibility of Cryptococcus neoformans isolates in HIV-infected patients to fluconazole, itraconazole and voriconazole in Spain: 1994-1996 and 1997-2005.西班牙1994 - 1996年及1997 - 2005年HIV感染患者中新型隐球菌分离株对氟康唑、伊曲康唑和伏立康唑的抗真菌药敏情况
Chemotherapy. 2007;53(4):300-5. doi: 10.1159/000102585. Epub 2007 May 10.
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Cryptococcus neoformans in organ transplant recipients: impact of calcineurin-inhibitor agents on mortality.器官移植受者中的新型隐球菌：钙调神经磷酸酶抑制剂对死亡率的影响。
J Infect Dis. 2007 Mar 1;195(5):756-64. doi: 10.1086/511438. Epub 2007 Jan 23.
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Results obtained with various antifungal susceptibility testing methods do not predict early clinical outcome in patients with cryptococcosis.采用各种抗真菌药敏试验方法所获得的结果并不能预测隐球菌病患者的早期临床结局。
Antimicrob Agents Chemother. 2006 Jul;50(7):2464-70. doi: 10.1128/AAC.01520-05.
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Combination of voriconazole and caspofungin as primary therapy for invasive aspergillosis in solid organ transplant recipients: a prospective, multicenter, observational study.伏立康唑与卡泊芬净联合作为实体器官移植受者侵袭性曲霉病的初始治疗：一项前瞻性、多中心、观察性研究。
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Cryptococcosis after solid organ transplantation.实体器官移植后的隐球菌病。
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7
In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus isolates from transplant and nontransplant patients.抗真菌药物与免疫抑制剂对来自移植患者和非移植患者的烟曲霉分离株的体外相互作用。
Antimicrob Agents Chemother. 2004 Dec;48(12):4922-5. doi: 10.1128/AAC.48.12.4922-4925.2004.
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Synergy, antagonism, and what the chequerboard puts between them.协同作用、拮抗作用，以及棋盘法介于两者之间的情况。
J Antimicrob Chemother. 2003 Jul;52(1):1. doi: 10.1093/jac/dkg301. Epub 2003 Jun 12.
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Combination of caspofungin with inhibitors of the calcineurin pathway attenuates growth in vitro in Aspergillus species.卡泊芬净与钙调神经磷酸酶途径抑制剂联合使用可减弱曲霉属真菌在体外的生长。
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10
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