Kontoyiannis Dimitrios P, Lewis Russell E, Osherov Nir, Albert Nathaniel D, May Gregory S
Department of Infectious Diseases, Infection Control & Employee Health, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Box 402, Houston, TX 77030, USA.
J Antimicrob Chemother. 2003 Feb;51(2):313-6. doi: 10.1093/jac/dkg090.
Work in Saccharomyces cerevisiae and Cryptococcus neoformans suggests that caspofungin could interact with the calcineurin pathway. We examined the in vitro interaction of caspofungin with calcineurin inhibitors (FK506, cyclosporin, FK520 and L685,818) and the TOR inhibitor rapamycin in 13 isolates of Aspergillus species. Caspofungin activity was enhanced by calcineurin/TOR inhibitors for all Aspergillus isolates studied. Further investigation of this pathway is warranted.
在酿酒酵母和新型隐球菌中的研究表明，卡泊芬净可能与钙调神经磷酸酶信号通路相互作用。我们检测了卡泊芬净与钙调神经磷酸酶抑制剂（FK506、环孢素、FK520和L685,818）以及雷帕霉素（一种TOR抑制剂）在13株曲霉菌分离株中的体外相互作用。对于所有研究的曲霉菌分离株，钙调神经磷酸酶/TOR抑制剂均可增强卡泊芬净的活性。有必要对该信号通路进行进一步研究。
