Perkins Bruce A, Orszag Andrej, Grewal Jaspreet, Ng Eduardo, Ngo Mylan, Bril Vera
Division of Endocrinology, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Diabetes Care. 2008 Mar;31(3):522-4. doi: 10.2337/dc07-1227. Epub 2007 Dec 10.
We aimed to establish whether multi-nerve testing with a point-of-care nerve conduction device could be used to diagnose diabetic sensorimotor polyneuropathy.
A total of 72 consecutive patients with diabetes underwent a full neurological examination and a concurrent evaluation for nine standard electrophysiological parameters using conventional nerve conduction studies (the reference standard) and a point-of-care device.
Spearman coefficients for correlation of point-of-care and conventional parameters ranged between 0.76 and 0.91 (P < 0.001 in all comparisons). Agreement by the method of Bland and Altman was acceptable despite small systematic biases. Fifty subjects (69%) had neuropathy according to conventional criteria. The sensitivity and specificity for the point-of-care device to identify such neuropathy was 88 and 82%, respectively.
A novel point-of-care device has reasonable diagnostic accuracy and thus may represent a sufficiently accurate alternative for detecting the diffuse electrophysiological criteria necessary to make the diagnosis of diabetic sensorimotor polyneuropathy.
我们旨在确定使用即时护理神经传导设备进行多神经测试是否可用于诊断糖尿病感觉运动性多发性神经病变。
共有72例连续的糖尿病患者接受了全面的神经学检查，并同时使用传统神经传导研究（参考标准）和即时护理设备对九个标准电生理参数进行评估。
即时护理参数与传统参数的Spearman相关系数在0.76至0.91之间（所有比较中P<0.001）。尽管存在较小的系统偏差，但Bland和Altman方法的一致性是可接受的。根据传统标准，50名受试者（69%）患有神经病变。即时护理设备识别此类神经病变的敏感性和特异性分别为88%和82%。
一种新型即时护理设备具有合理的诊断准确性，因此可能是检测诊断糖尿病感觉运动性多发性神经病变所需的弥漫性电生理标准的足够准确的替代方法。
