Sarma Aruna V, Burke James P, Jacobson Debra J, McGree Michaela E, St Sauver Jennifer, Girman Cynthia J, Lieber Michael M, Herman William, Macoska Jill, Montie James E, Jacobsen Steven J
Department of Urology, University of Michigan, Ann Arbor, Michigan, USA.
Diabetes Care. 2008 Mar;31(3):476-82. doi: 10.2337/dc07-1148. Epub 2007 Dec 10.
The aim of this study was to examine associations between diabetes and clinical markers of benign prostatic hyperplasia (BPH) in community-dwelling white and black men aged 40-79 years.
Data from the Olmsted County Study of Urinary Symptoms and Health Status and the Flint Men's Health Study were combined for a total study sample of 2,484 men. Severity of lower urinary tract symptoms (LUTS), peak urinary flow rates, prostate volume, and serum prostate-specific antigen (PSA) levels were examined by self-reported physician-diagnosed diabetes.
Overall, 170 men (6.8%) reported a history of diabetes. Increased irritative LUTS and specifically nocturia were positively associated with diabetes. These patterns were consistent across race and persisted after adjustment for age, BMI, and various indicators of socioeconomic status. Furthermore, the relationship between irritative LUTS and diabetes was greater in black men. No significant associations were observed between diabetes and prostate volume, PSA level, and peak urinary flow rate.
Our multiethnic community-based study demonstrates positive associations between diabetes and irritative LUTS and nocturia. Moreover, the association between irritative LUTS and diabetes is increased in black men. There was no strong evidence for an association between diabetes and BPH across measures more specific to BPH (i.e., prostate volume, PSA, and peak urinary flow rate). Taken together, our findings suggest that the presence of diabetes may be less related to prostate growth and more related to the dynamic components of lower urinary tract function. Further evaluations of the association between diabetes and BPH and related racial variations are warranted.
本研究旨在探讨40 - 79岁社区居住的白人和黑人男性中，糖尿病与良性前列腺增生（BPH）临床指标之间的关联。
将来自奥姆斯特德县泌尿系统症状与健康状况研究以及弗林特男性健康研究的数据合并，形成一个包含2484名男性的总研究样本。通过自我报告的医生诊断糖尿病情况，对下尿路症状（LUTS）的严重程度、最大尿流率、前列腺体积和血清前列腺特异性抗原（PSA）水平进行检测。
总体而言，170名男性（6.8%）报告有糖尿病病史。刺激性LUTS增加，尤其是夜尿症与糖尿病呈正相关。这些模式在不同种族中一致，并且在调整年龄、体重指数（BMI）和社会经济地位的各种指标后仍然存在。此外，刺激性LUTS与糖尿病之间的关系在黑人男性中更为明显。未观察到糖尿病与前列腺体积、PSA水平和最大尿流率之间存在显著关联。
我们基于多民族社区的研究表明，糖尿病与刺激性LUTS和夜尿症之间存在正相关。此外，刺激性LUTS与糖尿病之间的关联在黑人男性中更强。对于更具BPH特异性的指标（即前列腺体积、PSA和最大尿流率），没有有力证据表明糖尿病与BPH之间存在关联。综合来看，我们的研究结果表明，糖尿病的存在可能与前列腺生长关系较小，而与下尿路功能的动态成分关系更大。有必要进一步评估糖尿病与BPH之间的关联以及相关的种族差异。
