University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
BJU Int. 2011 Oct;108(8):1302-8. doi: 10.1111/j.1464-410X.2010.09991.x. Epub 2011 Mar 4.
• To compare prostate cancer, prostate-related surgery and acute urinary retention rates, as well as associated healthcare resource use over 11 years in African American and Caucasian men with benign prostatic hyperplasia (BPH).
• The BPH-related medical and surgical charges and events were determined for 398 African American men and 1656 Caucasian men followed for a mean of 10.2 years within a health maintenance organization. • Racial differences in clinical outcomes were evaluated using time-to-event analysis, stratifying results by baseline prostate-specific antigen (PSA) values.
• Risk of a prostate cancer diagnosis was 2.2 times greater in African American than Caucasian men (95% CI 1.48-3.35, P < 0.001) in analyses adjusting for serum PSA level. • Although African Americans were more likely to receive medical therapy for symptoms of BPH than Caucasians (43.5% vs 37.2%, respectively; P= 0.029), there were no clinically meaningful differences with respect to subsequent acute urinary retention or BPH-related surgery between them, or BPH-related medical charges (US $407 vs US $405 per month).
• As evidenced by this analysis of 'real-world' clinical practice, African Americans with BPH have a much greater risk of developing prostate cancer than similar Caucasian men highlighting the need for education and early detection in this population.
比较前列腺癌、前列腺相关手术和急性尿潴留的发生率，以及 11 年来在患有良性前列腺增生症（BPH）的非裔美国男性和白种男性中的相关医疗资源使用情况。
在一个健康维护组织中，对 398 名非裔美国男性和 1656 名白种男性进行了 BPH 相关的医疗和手术费用以及事件的确定，这些患者的平均随访时间为 10.2 年。使用时间事件分析评估种族间的临床结果差异，根据基线前列腺特异性抗原（PSA）值分层结果。
在调整血清 PSA 水平的分析中，非裔美国人患前列腺癌的风险是非裔美国人的 2.2 倍（95%CI 1.48-3.35，P<0.001）。尽管非裔美国人比白种人更有可能接受 BPH 症状的药物治疗（分别为 43.5%和 37.2%；P=0.029），但在随后的急性尿潴留或 BPH 相关手术方面，他们之间或 BPH 相关的医疗费用（每月 US$407 与 US$405）并没有明显的差异。
根据对“真实世界”临床实践的分析，患有 BPH 的非裔美国人比类似的白种男性患前列腺癌的风险要大得多，这突出了在这一人群中进行教育和早期检测的必要性。
