St Sauver Jennifer L, Sarma Aruna V, Jacobson Debra J, McGree Michaela E, Lieber Michael M, Girman Cynthia J, Nehra Ajay, Jacobsen Steven J
Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
Am J Epidemiol. 2009 Jun 1;169(11):1281-90. doi: 10.1093/aje/kwp085. Epub 2009 Apr 24.
Inflammation may play a role in the development of benign prostatic hyperplasia and/or lower urinary tract symptoms (LUTS). Higher levels of C-reactive protein (CRP) may therefore be associated with the development of these outcomes. The authors examined the association of CRP levels measured in 1996 with rapid increases in prostate volume, prostate-specific antigen levels, and LUTS as well as rapid decreases in peak flow rates (through 2005) in a population-based cohort of men residing in Olmsted County, Minnesota. Men with CRP levels of > or =3.0 mg/L were more likely to have rapid increases in irritative LUTS (odds ratio (OR) = 2.14, 95% confidence interval (CI): 1.18, 3.85) and rapid decreases in peak flow rates (OR = 2.54, 95% CI: 1.09, 5.92) compared with men with CRP levels of <3.0 mg/L. CRP levels were not significantly associated with rapid increases in prostate volume, obstructive LUTS, or prostate-specific antigen levels. Associations were attenuated after adjusting for age, body mass index, hypertension, and smoking history (irritative LUTS: OR = 2.00, 95% CI: 1.04, 3.82; peak flow rate: OR = 2.45, 95% CI: 0.73, 8.25). These results suggest that rapid increases in irritative LUTS and rapid decreases in peak flow rates may be due to inflammatory processes.
炎症可能在良性前列腺增生和/或下尿路症状（LUTS）的发展中起作用。因此，较高水平的C反应蛋白（CRP）可能与这些结果的发生有关。作者在明尼苏达州奥尔姆斯特德县的一个基于人群的男性队列中，研究了1996年测量的CRP水平与前列腺体积快速增加、前列腺特异性抗原水平、LUTS以及峰值流速快速下降（至2005年）之间的关联。与CRP水平<3.0 mg/L的男性相比，CRP水平≥3.0 mg/L的男性更有可能出现刺激性LUTS快速增加（优势比（OR）=2.14，95%置信区间（CI）：1.18，3.85）和峰值流速快速下降（OR = 2.54，95% CI：1.09，5.92）。CRP水平与前列腺体积快速增加、梗阻性LUTS或前列腺特异性抗原水平无显著关联。在调整年龄、体重指数、高血压和吸烟史后，关联减弱（刺激性LUTS：OR = 2.00，95% CI：1.04，3.82；峰值流速：OR = 2.45，95% CI：0.73，8.25）。这些结果表明，刺激性LUTS的快速增加和峰值流速的快速下降可能是由炎症过程引起的。
