Felix S B, Dörr M, Herda L R, Beug D, Staudt A
Klinik und Poliklinik für Innere Medizin B, Ernst-Moritz-Arndt-Universität Greifswald, Friedrich-Loeffler Strasse 23a, 17475, Greifswald, Deutschland.
Internist (Berl). 2008 Jan;49(1):51-6. doi: 10.1007/s00108-007-1991-x.
Abnormalities of the cellular and humoral immune system have been described in patients with dilated cardiomyopathy (DCM). For patients with DCM, immunochemical analyses of myocardial biopsies have demonstrated myocardial inflammation. Various circulating cardiac antibodies have been detected among DCM patients. Circulating antibodies are extractable by immunoadsorption. Recent open controlled pilot studies showed that removal of antibodies by immunoadsorption induces improvement of cardiac function in DCM. Furthermore, it decreases myocardial inflammation. This may offer a new therapeutic option for patients with severe heart failure due to dilated cardiomyopathy.
扩张型心肌病（DCM）患者存在细胞和体液免疫系统异常。对于DCM患者，心肌活检的免疫化学分析已证实存在心肌炎症。在DCM患者中检测到了多种循环心脏抗体。循环抗体可通过免疫吸附提取。最近的开放性对照试验研究表明，通过免疫吸附去除抗体可使DCM患者的心脏功能得到改善。此外，它还能减轻心肌炎症。这可能为因扩张型心肌病导致严重心力衰竭的患者提供一种新的治疗选择。
