Mizutani Kosuke, Ehara Hidetoshi, Yokoi Shigeaki, Phuoc Nguyen B, Deguchi Takashi, Hirose Yoshinobu
Department of Urology, Gifu University Hospital, Gifu, Japan.
Int J Clin Oncol. 2007 Dec;12(6):469-71. doi: 10.1007/s10147-007-0679-5. Epub 2007 Dec 21.
We report two cases of left ureteral carcinoma that may have been related to prior radiotherapy and anticancer chemotherapy for stage II testicular seminoma. Both patients had undergone radiotherapy (60 Gy) and cisplatin-based chemotherapy, one 17 years before the present presentation and the other 24 years earlier. They underwent retroperitoneoscopy-assisted left nephroureterectomy under a diagnosis of left upper ureteral cancer, established by means of ureteroscopy and brush biopsy. The urologic and radiologic outcomes have been satisfactory after more than 2 years of follow-up. Recently, some investigators have reported that testicular cancer survivors are at significantly increased risk of solid tumors for at least 35 years after treatment. Young patients may have a high risk of cancer when they reach an advanced age.
我们报告了两例左输尿管癌病例，这可能与之前针对II期睾丸精原细胞瘤进行的放射治疗和抗癌化疗有关。两名患者均接受过放射治疗（60 Gy）和顺铂为基础的化疗，一名患者在本次就诊前17年接受过治疗，另一名患者则是在24年前。他们在输尿管镜检查和刷检确诊为左上输尿管癌后，接受了后腹腔镜辅助下的左肾输尿管切除术。经过两年多的随访，泌尿外科和影像学检查结果均令人满意。最近，一些研究人员报告称，睾丸癌幸存者在治疗后至少35年内患实体瘤的风险显著增加。年轻患者在步入老年时可能患癌风险较高。
