de Hollander J A
Gist-Brocades, Delft, The Netherlands.
Antonie Van Leeuwenhoek. 1991 Oct-Nov;60(3-4):257-73. doi: 10.1007/BF00430369.
A general method is described, which enables the derivation of predictive fermentation equations for any microbiological process. The method combines the well-known achievements of the elemental balance approach with microscopic, metabolic balances and biochemical restrictions, using the key intermediates concept. Special attention is paid to the distinction between independent and dependent flow variables of a system. The method is fully illustrated for the very simple example of heterotrophic growth on a single substrate without product formation. Other examples include growth on mixed substrates and the description of catabolic and anabolic product formation.
本文描述了一种通用方法，该方法能够推导任何微生物过程的预测发酵方程。该方法结合了元素平衡法的著名成果与微观代谢平衡和生化限制条件，采用关键中间体概念。特别关注系统中独立和非独立流动变量之间的区别。通过一个非常简单的例子，即单一底物上无产物形成的异养生长，对该方法进行了充分说明。其他例子包括混合底物上的生长以及分解代谢和合成代谢产物形成的描述。
