一名服用过量噻加宾的儿科患者发生癫痫发作。
Seizures in a pediatric patient with a tiagabine overdose.
作者信息
Kazzi Ziad N, Jones Chris C, Morgan Brent W
机构信息
Department of Emergency Medicine, University of Alabama at Birmingham, USA.
出版信息
J Med Toxicol. 2006 Dec;2(4):160-2. doi: 10.1007/BF03161185.
INTRODUCTION
Tiagabine (TGB) is a novel antiepileptic that decreases GABA uptake. The literature contains one report of an adult with epilepsy who ingested up to 1 gram of TGB and developed status epilepticus. We reported on a pediatric patient who ingested significantly less TGB but still developed tonic-clonic seizures.
CASE REPORT
A previously healthy, 13 kg, two-year-old girl developed generalized tonic-clonic seizure activity at home approximately 1 hour after ingesting 90 mg of her grandmother's TGB (forty five 2 mg tablets). At the hospital she had two 5 minute seizures at 1.5 and 3.5 hours post ingestion. Her serum TGB levels were 530 and 130 ng/ml approximately 5 and 11 hours post-ingestion (5-70 ng/ml trough levels with most probable range for seizure control). She was discharged 27 hours post ingestion, and she was in good condition.
CONCLUSION
An overdose of TGB, a novel anti-epileptic, can cause convulsive seizures.
引言
噻加宾（TGB）是一种新型抗癫痫药物，可减少γ-氨基丁酸（GABA）的摄取。文献中有一篇报道称，一名成年癫痫患者摄入了多达1克的噻加宾并引发了癫痫持续状态。我们报告了一名儿科患者，其摄入的噻加宾量明显较少，但仍出现了强直阵挛性发作。
病例报告
一名此前健康的13公斤重的两岁女孩，在摄入90毫克她祖母的噻加宾（四十五片2毫克片剂）后约1小时在家中出现全身性强直阵挛性发作活动。在医院，她在摄入药物后1.5小时和3.5小时各发作了一次持续5分钟的癫痫。摄入药物后约5小时和11小时，她的血清噻加宾水平分别为530纳克/毫升和130纳克/毫升（谷浓度为5 - 70纳克/毫升，最可能的癫痫控制范围）。摄入药物后27小时她出院，身体状况良好。
结论
过量服用新型抗癫痫药物噻加宾可导致惊厥性癫痫发作。
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