Leach J P, Stolarek I, Brodie M J
University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland, UK.
Seizure. 1995 Jun;4(2):155-7. doi: 10.1016/s1059-1311(95)80098-0.
Tiagabine is a novel antiepileptic drug which acts by decreasing gamma aminobutyric acid uptake in astrocytes and neurones. Here the first case of deliberate overdose with this compound in a patient on concomitant phenytoin is reported. On admission to hospital his conscious level deteriorated to grade III coma. No changes in the electrocardiogram were noted. Recovery from the initial effects was rapid, and there were no sequelae. Plasma levels of tiagabine (3.1 micrograms/ml) 4 hours after ingestion were 30 times higher than at typical steady state during therapeutic dosing. The effects of poisoning with current first-line antiepileptic drugs are reviewed. The newer agents, particularly those with greater biochemical specificity, may be safer in overdose than the more established anticonvulsants.
噻加宾是一种新型抗癫痫药物，其作用机制是减少星形胶质细胞和神经元中γ-氨基丁酸的摄取。本文报告了首例同时服用苯妥英的患者故意过量服用该化合物的病例。入院时，他的意识水平恶化为III级昏迷。未观察到心电图变化。最初的影响恢复迅速，且无后遗症。摄入后4小时血浆噻加宾水平（3.1微克/毫升）比治疗剂量时的典型稳态水平高30倍。本文回顾了目前一线抗癫痫药物中毒的影响。新型药物，尤其是那些具有更高生化特异性的药物，过量服用时可能比更常用的抗惊厥药物更安全。
