鞘内注射巴氯芬撤药并发可逆性心肌病：一例报告
Reversible cardiomyopathy complicating intrathecal baclofen withdrawal: a case report.
作者信息
Pizon Anthony F, Lovecchio Frank
机构信息
University of Pittsburgh School of Medicine, Division of Medical Toxicology, Pittsburgh, PA, USA.
出版信息
J Med Toxicol. 2007 Dec;3(4):187-9. doi: 10.1007/BF03160938.
This case report is about reversible cardiomyopathy associated with intrathecal baclofen withdrawal. Previous literature has reported that enteral baclofen does not adequately control intrathecal baclofen withdrawal. In our case, coronary atherosclerosis did not play a role in the development of the cardiomyopathy. However, reinstitution of intrathecal baclofen promptly resulted in improvement. One could hypothesize that myocardial stunning from sympathetic hyperactivity led to a similar cardiomyopathy reported with catecholamine excess or acute sympathomimetic poisoning.
本病例报告是关于与鞘内注射巴氯芬撤药相关的可逆性心肌病。既往文献报道口服巴氯芬不能充分控制鞘内注射巴氯芬撤药。在我们的病例中，冠状动脉粥样硬化在心肌病的发生中未起作用。然而，重新鞘内注射巴氯芬后症状迅速改善。有人可能推测，交感神经过度兴奋导致的心肌顿抑引发了与儿茶酚胺过量或急性拟交感神经药中毒所报道的类似心肌病。
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