Vozzi Giovanni, Rechichi Alfonsina, Dini Francesca, Salvadori Claudia, Vozzi Federico, Burchielli Silvia, Carlucci Fabio, Arispici Mario, Ciardelli Gianluca, Giusti Paolo, Ahluwalia Arti
Department of Chemical Engineering, Industrial Chemistry and Science of Materials, Interdepartmental Research Center E. Piaggio, Faculty of Engineering, University of Pisa, Via Diotisalvi 2, Pisa, Italy.
Macromol Biosci. 2008 Jan 9;8(1):60-8. doi: 10.1002/mabi.200700214.
Polymeric scaffolds were realised with linear degradable PU in the form of square, hexagonal and octagonal grids. They were characterised in terms of their mechanical properties. Analysis shows that the mechanical properties of the scaffolds depend on their geometries which are easily modulated using PAM. In vitro biological assays showed that PU promotes the adhesion and proliferation of fibroblast cells and that cell activities are better on PU scaffolds than on PU films. In vivo implantation of PU and PLGA scaffolds and PU films demonstrated that the scaffolds are completely resorbed after three months with a slight inflammatory response, while the PU film was still present after six months with an intense granulomatous reaction.
采用线性可降解聚氨酯制备了方形、六边形和八边形网格形式的聚合物支架。对其力学性能进行了表征。分析表明，支架的力学性能取决于其几何形状，而这些几何形状可通过聚酰胺轻松调节。体外生物学试验表明，聚氨酯促进成纤维细胞的黏附和增殖，且在聚氨酯支架上的细胞活性优于在聚氨酯薄膜上的细胞活性。聚氨酯和聚乳酸-羟基乙酸共聚物支架以及聚氨酯薄膜的体内植入实验表明，三个月后支架完全被吸收，伴有轻微炎症反应，而六个月后聚氨酯薄膜仍存在，伴有强烈的肉芽肿反应。
