Os I, Hjermann I, Nordby G
Nyreavdelingen, Ullevål sykehus, Oslo.
Tidsskr Nor Laegeforen. 1991 Oct 20;111(25):3062-4.
Hypertension is only one of several cardiovascular risk factors that tend to cluster. Hypertension is associated with glucose intolerance, hyperinsulinemia, decreased HDL-cholesterol, high triglycerides and decreased fibrinolytic activity. One possible link is insulin resistance, which also links hypertension to obesity and diabetes mellitus type II. The authors review the literature and discuss clinical and therapeutic implications in the treatment of hypertension. Since the hypertensive patient may have an unfavourable cardiovascular risk profile, a non-pharmacological approach is essential in the treatment. Furthermore, if antihypertensive agents have to be used, metabolic side effects should be monitored closely, since they may reduce the beneficial effects of the blood pressure reduction on the cardiovascular risk profile.
高血压只是几种往往会聚集在一起的心血管危险因素之一。高血压与葡萄糖耐量异常、高胰岛素血症、高密度脂蛋白胆固醇降低、高甘油三酯以及纤溶活性降低有关。一个可能的联系是胰岛素抵抗，它也将高血压与肥胖和II型糖尿病联系起来。作者回顾了文献并讨论了高血压治疗中的临床和治疗意义。由于高血压患者可能有不利的心血管风险状况，非药物治疗方法在治疗中至关重要。此外，如果必须使用抗高血压药物，应密切监测代谢副作用，因为它们可能会降低血压降低对心血管风险状况的有益作用。
