Blandino G, Milazzo I, Fazio D, Puglisi S, Pisano M, Speciale A, Pappalardo S
Department of Gynecological and Microbiological Sciences-Section of Microbiology, University of Catania, Italy.
J Chemother. 2007 Oct;19(5):495-9. doi: 10.1179/joc.2007.19.5.495.
Most suppurative orofacial infections are polymicrobial. Information regarding the antimicrobial susceptibility of the microorganisms involved can be useful in the choice of an effective antibiotic therapy. In this study we determined the antimicrobial susceptibility of a total 235 anaerobic and aerobic bacteria recently isolated from pus specimens of orofacial infections. All the viridans streptococci were susceptible to penicillin, cefotaxime, cefoxitin, imipenem and levofloxacin. Imipenem and levofloxacin were active against 100% of the anaerobic Gram-positive organisms isolated. Among the anaerobic Gram-negative rods beta-lactamase production was detected in all species except Campylobacter rectus. Amoxicillin-clavulanate, cefoxitin, imipenem and metronidazole were active against all the isolates of anaerobic Gram-negative species. Isolates resistant to erythromycin were found in all the species tested, however, resistance to clindamycin was only detected in Porphyromonas gingivalis and Bacteroides ureolyticus. Isolates resistant to levofloxacin were detected in P. gingivalis and Prevotella sp.
大多数化脓性口腔面部感染是多微生物感染。有关所涉及微生物的抗菌药敏性信息有助于选择有效的抗生素治疗。在本研究中，我们测定了最近从口腔面部感染的脓液标本中分离出的总共235株厌氧菌和好氧菌的抗菌药敏性。所有草绿色链球菌对青霉素、头孢噻肟、头孢西丁、亚胺培南和左氧氟沙星敏感。亚胺培南和左氧氟沙星对分离出的100%厌氧革兰氏阳性菌有活性。在厌氧革兰氏阴性杆菌中，除直肠弯曲菌外，所有菌种均检测到β-内酰胺酶产生。阿莫西林-克拉维酸、头孢西丁、亚胺培南和甲硝唑对所有厌氧革兰氏阴性菌分离株均有活性。在所有测试菌种中均发现了对红霉素耐药的分离株，然而，仅在牙龈卟啉单胞菌和解脲拟杆菌中检测到对克林霉素的耐药性。在牙龈卟啉单胞菌和普雷沃菌属中检测到对左氧氟沙星耐药的分离株。
