Kuriyama T, Karasawa T, Nakagawa K, Yamamoto E, Nakamura S
Department of Oral and Maxillofacial Surgery, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan.
Oral Microbiol Immunol. 2002 Apr;17(2):132-5. doi: 10.1046/j.0902-0055.2001.00098.x.
We recently reported the beta-lactamase production and antimicrobial susceptibility of anaerobic gram-negative rods isolated from pus specimens of 93 orofacial odontogenic infections. In this report, we determine the bacteriology and antimicrobial susceptibility of bacteria other than anaerobic gram-negative rods, mainly gram-positive cocci, isolated from the same specimens. Streptococcus constellatus and Peptostreptococcus micros were frequent isolates from all types of infection examined. Peptostreptococcus prevotii, Corynebacterium species, and Eubacterium species were recovered only from dentoalveolar infections, while Gemella morbillorum was found more frequently in periodontitis than in the other infections. beta-Lactamase-positive strains were detected only in staphylococci. Ampicillin, ampicillin/sulbactam, cefazolin, cefotaxime, imipenem, erythromycin, clindamycin and levofloxacin showed high susceptibility rates (> or = 77%) against viridans streptococci, Peptostreptococcus and Gemella. Minocycline showed a high MIC90 value against viridans streptococci (32 microg/ml), and metronidazole was effective against Peptostreptococcus and Gemella. These results provide useful information for the treatment of orofacial odontogenic infections.
我们最近报告了从93例口腔颌面部牙源性感染的脓液标本中分离出的厌氧革兰氏阴性杆菌的β-内酰胺酶产生情况及抗菌药敏性。在本报告中，我们确定了从相同标本中分离出的除厌氧革兰氏阴性杆菌以外的细菌的细菌学及抗菌药敏性，这些细菌主要是革兰氏阳性球菌。星座链球菌和微小消化链球菌是在所检查的所有类型感染中常见的分离菌。普氏消化链球菌、棒状杆菌属和真杆菌属仅从牙槽感染中分离得到，而麻疹孪生球菌在牙周炎中比在其他感染中更常见。仅在葡萄球菌中检测到β-内酰胺酶阳性菌株。氨苄西林、氨苄西林/舒巴坦、头孢唑林、头孢噻肟、亚胺培南、红霉素、克林霉素和左氧氟沙星对草绿色链球菌、消化链球菌和孪生球菌显示出高敏感率（≥77%）。米诺环素对草绿色链球菌显示出高MIC90值（32μg/ml），甲硝唑对消化链球菌和孪生球菌有效。这些结果为口腔颌面部牙源性感染的治疗提供了有用信息。
