在静脉结扎模型中，剪切应力对鸡胚发育中心血管系统中内皮素-1（ET-1）、 Kruppel样因子2（KLF2）和一氧化氮合酶3（NOS-3）表达的作用。
The role of shear stress on ET-1, KLF2, and NOS-3 expression in the developing cardiovascular system of chicken embryos in a venous ligation model.
作者信息
Groenendijk Bianca C W, Van der Heiden Kim, Hierck Beerend P, Poelmann Robert E
机构信息
Department of Medical Biochemistry, Academic Medical Center, Amsterdam, The Netherlands.
出版信息
Physiology (Bethesda). 2007 Dec;22:380-9. doi: 10.1152/physiol.00023.2007.
In this review, the role of wall shear stress in the chicken embryonic heart is analyzed to determine its effect on cardiac development through regulating gene expression. Therefore, background information is provided for fluid dynamics, normal chicken and human heart development, cardiac malformations, cardiac and vitelline blood flow, and a chicken model to induce cardiovascular anomalies. A set of endothelial shear stress-responsive genes coding for endothelin-1 (ET-1), lung Krüppel-like factor (LKLF/KLF2), and endothelial nitric oxide synthase (eNOS/NOS-3) are active in development and are specifically addressed.
在本综述中，分析了壁面剪应力在鸡胚心脏中的作用，以确定其通过调节基因表达对心脏发育的影响。因此，提供了关于流体动力学、正常鸡和人类心脏发育、心脏畸形、心脏和卵黄囊血流以及诱导心血管异常的鸡模型的背景信息。一组编码内皮素-1（ET-1）、肺Krüppel样因子（LKLF/KLF2）和内皮型一氧化氮合酶（eNOS/NOS-3）的内皮剪应力反应基因在发育过程中具有活性，并将被专门讨论。
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