Cockram James, Mackay Ian J, O'Sullivan Donal M
National Institute of Agricultural Botany, Cambridge CB3 0LE, United Kingdom.
Genetics. 2007 Dec;177(4):2535-9. doi: 10.1534/genetics.107.074765.
Nonhomologous repair of double-stranded breaks, although fundamental to the maintenance of genomic integrity in all eukaryotes, has received little attention as to its evolutionary consequences in the generation and selection of phenotypic diversity. Here we document the role of illegitimate recombination in the creation of novel alleles in VRN1 orthologs selected to confer adaptation to annual cropping systems in barley and wheat.
双链断裂的非同源修复虽然对于所有真核生物维持基因组完整性至关重要，但在表型多样性的产生和选择过程中，其进化后果却很少受到关注。在这里，我们记录了非法重组在大麦和小麦中被选择用于适应一年生种植系统的VRN1直系同源基因中产生新等位基因的作用。
