Vandecasteele G, Szabadkai G, Rizzuto R
Department of Experimental and Diagnostic Medicine, Center for the Study of Inflammatory Diseases (CESMI), University of Ferrara, Italy.
IUBMB Life. 2001 Sep-Nov;52(3-5):213-9. doi: 10.1080/15216540152846028.
Despite the early characterisation of Ca2+ fluxes in isolated mitochondria and the ability of this ion to up-regulate dehydrogenases of the Krebs cycle, the low affinity of the organelle uptake pathways was a long-standing obstacle to the recognition of a physiological role for mitochondrial Ca2+ uptake. This review begins with a historical account of the main results that proved the contrary and provides a brief description of mitochondrial Ca2+ signals. Then, it discusses the characteristics of Ca2+ regulation of mitochondrial function. Finally, it summarizes recent discoveries on structural aspects of mitochondrial reticulum and its connections to signalling partners such as the endoplasmic reticulum or the plasma membrane.
尽管在分离的线粒体中对Ca2+通量进行了早期表征，且该离子具有上调三羧酸循环脱氢酶的能力，但细胞器摄取途径的低亲和力长期以来一直阻碍着人们认识线粒体Ca2+摄取的生理作用。本综述首先对证明相反观点的主要结果进行了历史回顾，并简要描述了线粒体Ca2+信号。然后，讨论了Ca2+对线粒体功能调节的特征。最后，总结了线粒体网状结构及其与内质网或质膜等信号伙伴连接的结构方面的最新发现。
