Weldon Sinead, Taggart Clifford C
School of Medicine and Dentistry, Queen's University Belfast, Belfast, Northern Ireland.
Exp Lung Res. 2007 Dec;33(10):485-91. doi: 10.1080/01902140701756547.
Chronic lung diseases such as cystic fibrosis and emphysema are characterized by a protease burden, an infective process and a dominant proinflammatory profile. Secretory leucoprotease inhibitor (SLPI) is a prominent innate immune protein of the respiratory tract, possessing serine protease inhibitor activity, antibacterial activity, and anti-inflammatory/immunomodulatory activity. In the course of this review, the authors highlight the findings from a range of studies that illustrate the multiple functions of SLPI and its role in the resolution of the immune response.
诸如囊性纤维化和肺气肿之类的慢性肺部疾病的特征在于蛋白酶负荷、感染过程和主要的促炎特征。分泌性白细胞蛋白酶抑制剂（SLPI）是呼吸道一种重要的固有免疫蛋白，具有丝氨酸蛋白酶抑制活性、抗菌活性和抗炎/免疫调节活性。在本综述过程中，作者强调了一系列研究的结果，这些结果阐明了SLPI的多种功能及其在免疫反应消退中的作用。
