哺乳动物减数分裂重组热点

Mammalian meiotic recombination hot spots.

作者信息

Arnheim Norman, Calabrese Peter, Tiemann-Boege Irene

机构信息

Molecular and Computational Biology Program, University of Southern California, Los Angeles, CA 90089-2910, USA.

出版信息

Annu Rev Genet. 2007;41:369-99. doi: 10.1146/annurev.genet.41.110306.130301.

DOI:10.1146/annurev.genet.41.110306.130301

PMID:18076329

Abstract

Our understanding of the details of mammalian meiotic recombination has recently advanced significantly. Sperm typing technologies, linkage studies, and computational inferences from population genetic data have together provided information in unprecedented detail about the location and activity of the sites of crossing-over in mice and humans. The results show that the vast majority of meiotic recombination events are localized to narrow DNA regions (hot spots) that constitute only a small fraction of the genome. The data also suggest that the molecular basis of hot spot activity is unlikely to be strictly determined by specific DNA sequence motifs in cis. Further molecular studies are needed to understand how hot spots originate, function and evolve.

摘要

我们对哺乳动物减数分裂重组细节的理解最近有了显著进展。精子分型技术、连锁研究以及从群体遗传数据进行的计算推断，共同以前所未有的详细程度提供了关于小鼠和人类交叉位点位置和活性的信息。结果表明，绝大多数减数分裂重组事件定位于狭窄的DNA区域（热点），这些区域仅占基因组的一小部分。数据还表明，热点活性的分子基础不太可能由顺式中的特定DNA序列基序严格决定。需要进一步的分子研究来了解热点是如何起源、发挥功能和进化的。