Frazier Jean A, Breeze Janis L, Papadimitriou George, Kennedy David N, Hodge Steven M, Moore Constance M, Howard James D, Rohan Michael P, Caviness Verne S, Makris Nikos
Department of Psychiatry, Harvard Medical School, Boston, USA.
Bipolar Disord. 2007 Dec;9(8):799-809. doi: 10.1111/j.1399-5618.2007.00482.x.
Diffusion tensor magnetic resonance imaging (DT-MRI) assesses the integrity of white matter (WM) tracts in the brain. Children with bipolar disorder (BPD) may have WM abnormalities that precede illness onset. To more fully examine this possibility, we scanned children with DSM-IV BPD and compared them to healthy peers and children at risk for BPD (AR-BPD), defined as having a first-degree relative with the disorder.
Ten children with BPD, eight healthy controls (HC), and seven AR-BPD, similar in age, had MRI scans on a 1.5 Tesla GE scanner, including a standard DT-MRI sequence (T2-EPI) with 25 axial slices. Fractional anisotropy (FA) values were compared between groups to determine regions of significant difference (p < 0.05).
Compared to HC, children with BPD had decreased FA in right and left superior frontal tracts, including the superior longitudinal fasciculus I (SLF I) and the cingulate-paracingulate WM (CG-PAC(WM)). In addition, the BPD group had reduced FA in left orbital frontal WM and the right corpus callosum body. Compared to AR-BPD, children with BPD showed reduced FA in the right and left CG-PAC(WM). Both the BPD and AR-BPD groups showed reduced FA relative to HC in bilateral SLF I.
The bilateral SLF I finding in both the BPD and AR-BPD groups may represent a trait-based marker or endophenotype of the disorder. The finding of decreased FA in the right and left CG-PAC(WM) in children with BPD compared to the other two groups may represent a disease-state related finding.
扩散张量磁共振成像（DT-MRI）用于评估大脑白质（WM）束的完整性。双相情感障碍（BPD）儿童可能在疾病发作前就存在WM异常。为了更全面地研究这种可能性，我们对患有DSM-IV BPD的儿童进行了扫描，并将他们与健康同龄人以及有BPD风险的儿童（AR-BPD，定义为有该疾病的一级亲属）进行了比较。
10名患有BPD的儿童、8名健康对照（HC）和7名AR-BPD儿童，年龄相仿，在1.5特斯拉的GE扫描仪上进行了MRI扫描，包括一个具有25个轴向切片的标准DT-MRI序列（T2-EPI）。比较各组之间的分数各向异性（FA）值，以确定存在显著差异的区域（p < 0.05）。
与HC相比，患有BPD的儿童在左右额上束中的FA降低，包括上纵束I（SLF I）和扣带回-旁扣带回白质（CG-PAC(WM)）。此外，BPD组在左侧眶额白质和右侧胼胝体中的FA降低。与AR-BPD相比，患有BPD的儿童在左右CG-PAC(WM)中的FA降低。BPD组和AR-BPD组在双侧SLF I中的FA相对于HC均降低。
BPD组和AR-BPD组双侧SLF I的发现可能代表该疾病基于特质的标志物或内表型。与其他两组相比，BPD儿童左右CG-PAC(WM)中FA降低的发现可能代表与疾病状态相关的发现。
