Faraone Stephen V, Althoff Robert R, Hudziak James J, Monuteaux Michael, Biederman Joseph
Medical Genetics Research Program and Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
Bipolar Disord. 2005 Dec;7(6):518-24. doi: 10.1111/j.1399-5618.2005.00271.x.
No clear consensus has been reached yet on how best to characterize children who suffer from pediatric bipolar disorder (PBD). The CBCL-PBD profile on the Child Behavior Checklist (CBCL) has been consistently reported showing deviant findings on the Attention Problems, Aggressive Behavior, and Anxious-Depressed subscales.
To examine the sensitivity and specificity of the proposed CBCL-PBD profile for determining DSM diagnosis of PBD.
We applied receiver operating characteristic (ROC) curve analysis to data from 471 probands from two family studies of attention-deficit hyperactivity disorder and their 410 siblings.
The CBCL-PBD score demonstrated an area under the curve (AUC) of 0.97 for probands and 0.82 for siblings for current diagnosis of PBD, suggesting that the CBCL-PBD provided a highly efficient way of identifying subjects with a current diagnosis of PBD in this sample.
These findings suggest that the CBCL-PBD may provide a highly efficient way of screening for childhood bipolar disorder.
对于如何最好地描述患有儿童双相情感障碍（PBD）的儿童，目前尚未达成明确的共识。《儿童行为检查表》（CBCL）上的CBCL - PBD剖面图一直被报告显示在注意力问题、攻击性行为和焦虑抑郁分量表上有异常发现。
检验所提出的CBCL - PBD剖面图用于确定PBD的DSM诊断的敏感性和特异性。
我们将接受者操作特征（ROC）曲线分析应用于来自两项注意力缺陷多动障碍家庭研究的471名先证者及其410名兄弟姐妹的数据。
CBCL - PBD评分显示，对于先证者，当前诊断PBD的曲线下面积（AUC）为0.97，对于兄弟姐妹为0.82，这表明CBCL - PBD提供了一种在该样本中识别当前诊断为PBD的受试者的高效方法。
这些发现表明，CBCL - PBD可能提供一种高效的儿童双相情感障碍筛查方法。
