van den Heuvel Marianne J, Hatta Kota, Peralta Crystal G, Han Victor K, Clark David A
Department of Pediatrics, Children's Health Research Institute, University of Western Ontario, London, ON, Canada.
Am J Reprod Immunol. 2008 Feb;59(2):90-8. doi: 10.1111/j.1600-0897.2007.00546.x. Epub 2007 Nov 21.
Uterine natural killer (uNK) cells are enriched in the post-ovulatory uterus and during pregnancy. Whether these cells arise from blood pre-cursors or from stem cells in the uterus is undefined. To support a hypothesis that precursors of uNK cells are recruited from blood, adhesive function of blood CD56+ subsets were assessed during one cycle and during pregnancy.
Fifteen women of proven fertility provided serial blood samples during one menstrual cycle and thirty women with a history of implantation failure or recurrent spontaneous abortion provided serial samples during infertility treatment.
CD56(bright) cells, but not CD56(dim) cells or NKT cells, increased in ligand-binding capacity during ovulation in fertile cycles only and during the first 2 weeks from date of missed menses.
Enhanced adhesive function at ovulation in CD56(bright) cells in fertile cycles and during early gestation supports a hypothesis of recruitment of pre-uNK cells from the blood CD56(bright) subset.
子宫自然杀伤（uNK）细胞在排卵后子宫及孕期增多。这些细胞是源自血液前体细胞还是子宫中的干细胞尚不清楚。为支持uNK细胞前体从血液中募集的假说，在一个月经周期及孕期评估了血液CD56 +亚群的黏附功能。
15名已证实有生育能力的女性在一个月经周期内提供系列血样，30名有种植失败或反复自然流产史的女性在不孕治疗期间提供系列血样。
仅在有生育能力的周期排卵期间以及从月经推迟之日起的前2周内，CD56（明亮型）细胞而非CD56（暗淡型）细胞或NKT细胞的配体结合能力增强。
在有生育能力的周期排卵时以及妊娠早期，CD56（明亮型）细胞黏附功能增强，支持了从血液CD56（明亮型）亚群募集uNK前体细胞的假说。
