Hatta Kota, Bilinski Michael J, Haladyn J Kimberly, Roy Jessica J, Horrocks Julie, van den Heuvel Marianne J, Han Victor K, Croy B Anne
Department of Microbiology and Immunology, Queen's University, Kingston, ON, Canada.
Am J Reprod Immunol. 2009 Sep;62(3):158-64. doi: 10.1111/j.1600-0897.2009.00725.x.
To identify plasma immuno-regulatory molecules up or down regulated between the follicular phase and ovulation of the human menstrual cycle.
RayBio cytokine arrays were used to screen 174 immuno-regulatory molecules in plasma collected during the follicular phase at menstrual cycle day 5 and at ovulation from five healthy, non-smoking, fertile women of reproductive age not using hormonal contraception.
A total of 23 differentially expressed molecules were found: 10 molecules were differentially up-regulated and 13 down-regulated at ovulation compared with that at the follicular phase (alpha = 0.05, false discovery rate of 0.45).
Circulating immuno-regulatory molecules fluctuate over the menstrual cycle in healthy women. The combination of differentially expressed molecules suggests roles in cyclical regulation of angiogenesis and immune cell trafficking.
确定人类月经周期卵泡期和排卵期之间血浆中上调或下调的免疫调节分子。
使用RayBio细胞因子阵列筛选5名健康、不吸烟、处于生育年龄且未使用激素避孕的可育女性在月经周期第5天卵泡期和排卵期采集的血浆中的174种免疫调节分子。
共发现2-3种差异表达分子：与卵泡期相比，排卵期有10种分子差异上调，13种下调（α = 0.05，错误发现率为0.45）。
健康女性循环免疫调节分子在月经周期中波动。差异表达分子的组合提示其在血管生成和免疫细胞运输的周期性调节中发挥作用。
