男性镁摄入量对有症状胆结石疾病风险的长期影响。

Long-term effect of magnesium consumption on the risk of symptomatic gallstone disease among men.

作者信息

Tsai Chung-Jyi, Leitzmann Michael F, Willett Walter C, Giovannucci Edward L

机构信息

Division of Digestive Diseases and Nutrition, University of Kentucky Medical Center, Lexington, KY 40536-0298, USA.

出版信息

Am J Gastroenterol. 2008 Feb;103(2):375-82. doi: 10.1111/j.1572-0241.2007.01696.x. Epub 2007 Dec 12.

DOI:10.1111/j.1572-0241.2007.01696.x

PMID:18076730

Abstract

BACKGROUND

Magnesium deficiency can cause dyslipidemia and insulin hypersecretion, which may facilitate gallstone formation. However, the effect of long-term consumption of magnesium on the risk of gallstone disease is unknown.

METHODS

We prospectively studied magnesium consumption and risk of gallstone disease in a cohort of 42,705 U.S. men from 1986 to 2002. Magnesium consumption was assessed using a validated semiquantitative food frequency questionnaire. Newly diagnosed gallstone disease was ascertained biennially.

RESULTS

We documented 2,195 incident cases of symptomatic gallstones during 560,810 person-years of follow-up. The age-adjusted relative risks (RRs) for men with total magnesium intake and dietary magnesium, when the highest and lowest quintiles were compared, were 0.67 (95% confidence interval [CI] 0.59-0.77, P for trend <0.0001) and 0.67 (CI 0.59-0.76, P for trend <0.0001), respectively. After adjusting for multiple potential confounding variables, when extreme quintiles were compared, the multivariate RR of total magnesium intake (RR 0.72, CI 0.61-0.86, P for trend = 0.006) and dietary magnesium (RR 0.68, CI 0.57-0.82, P for trend = 0.0006) remained significant with a dose-response relationship.

CONCLUSIONS

Our findings suggest a protective role of magnesium consumption in the prevention of symptomatic gallstone disease among men.

摘要

背景

镁缺乏可导致血脂异常和胰岛素分泌过多，这可能促进胆结石形成。然而，长期摄入镁对胆结石疾病风险的影响尚不清楚。

方法

我们对1986年至2002年期间42705名美国男性队列中的镁摄入量与胆结石疾病风险进行了前瞻性研究。使用经过验证的半定量食物频率问卷评估镁摄入量。每两年确定一次新诊断的胆结石疾病。

结果

在560810人年的随访期间，我们记录了2195例有症状胆结石的发病病例。比较最高和最低五分位数时，总镁摄入量和膳食镁摄入量男性的年龄调整相对风险（RR）分别为0.67（95%置信区间[CI]0.59 - 0.77，趋势P<0.0001）和0.67（CI 0.59 - 0.76，趋势P<0.0001）。在调整多个潜在混杂变量后，比较极端五分位数时，总镁摄入量（RR 0.72，CI 0.61 - 0.86，趋势P = 0.006）和膳食镁摄入量（RR 0.68，CI 0.57 - 0.82，趋势P = 0.0006）的多变量RR仍然显著，且呈剂量反应关系。