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微粒体酶免疫分析和化学发光免疫分析检测HBeAg阴性慢性乙型肝炎病毒感染患者血清中抗-HBc免疫球蛋白M的性能特征

Performance characteristics of microparticle enzyme and chemiluminescence immunoassays for measurement of anti-HBc immunoglobulin M in sera of patients with HBeAg-negative chronic hepatitis B virus infection.

作者信息

Hadziyannis Emilia, Manesis Emanuel, Vassilopoulos Dimitrios, Georgiou Anastasia, Archimandritis Athanasios

机构信息

Academic Department of Medicine, Athens University School of Medicine, Hippokration General Hospital, 114 Vas. Sophias Ave., Athens 11527, Greece.

出版信息

Clin Vaccine Immunol. 2008 Feb;15(2):385-7. doi: 10.1128/CVI.00414-07. Epub 2007 Dec 12.

DOI:10.1128/CVI.00414-07
PMID:18077614
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2238054/
Abstract

The IMx, AxSym, and Architect immunoglobulin M anti-HBc assay systems for detecting hepatitis B virus e antigen-negative chronic hepatitis B virus infection were compared. Despite good intra- and interassay coefficients of variation, significantly different values and low correlation (overestimation by AxSym and underestimation by Architect) were observed. Association and cutoff values for distinguishing patients with viral replication should be established for all methods.

摘要

对用于检测乙型肝炎病毒e抗原阴性慢性乙型肝炎病毒感染的IMx、AxSym和Architect免疫球蛋白M抗-HBc检测系统进行了比较。尽管批内和批间变异系数良好，但观察到显著不同的值和低相关性（AxSym高估，Architect低估）。应为所有方法确定区分病毒复制患者的关联性和临界值。

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Poor response to 18-month lamivudine monotherapy in chronic hepatitis B patients with IgM anti-HBc and acute exacerbation.
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