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Moderate reduction of gamma-secretase: is there a therapeutic sweet spot?

作者信息

Choi Se Hoon, Norstrom Eric

机构信息

Committee on Neurobiology, University of Chicago, Chicago, Illinois 60637, USA.

出版信息

J Neurosci. 2007 Dec 12;27(50):13579-80. doi: 10.1523/JNEUROSCI.4821-07.2007.

Abstract
摘要

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本文引用的文献

1
Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities.
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2
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Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease.
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Notch signaling in lymphocyte development.
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gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?
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