鼠白血病病毒包膜蛋白的表达足以诱导细胞凋亡。
Expression of murine leukemia virus envelope protein is sufficient for the induction of apoptosis.
作者信息
Zhao Xiaoqing, Yoshimura Fayth K
机构信息
Department of Immunology and Microbiology, Wayne State University, 540 E. Canfield Ave., Detroit, MI 48201, USA.
出版信息
J Virol. 2008 Mar;82(5):2586-9. doi: 10.1128/JVI.02291-07. Epub 2007 Dec 12.
Abstract
The generation of cytopathic effects by murine leukemia viruses (MLVs) in different cell types correlates with the ability of the virus to induce thymic lymphoma. We showed that the induction of apoptosis in mink epithelial cells by mink cell focus-forming (MCF) MLV infection results in the accumulation of high levels of both unintegrated viral DNA and the envelope precursor polyprotein (gPr80(env)). Comparisons of envelope protein expression levels of plasmid clones of the env gene of the MCF13 and noncytopathic NZB-9 MLV strains demonstrated that the accumulation of MCF13 gPr80(env) results in endoplasmic reticulum stress and is sufficient for the induction of apoptosis.
摘要
小鼠白血病病毒（MLV）在不同细胞类型中产生细胞病变效应与该病毒诱导胸腺淋巴瘤的能力相关。我们发现，水貂细胞灶形成（MCF）MLV感染诱导水貂上皮细胞凋亡会导致高水平未整合病毒DNA和包膜前体多聚蛋白（gPr80(env)）的积累。对MCF13和无细胞病变的NZB-9 MLV毒株env基因的质粒克隆的包膜蛋白表达水平进行比较表明，MCF13 gPr80(env)的积累会导致内质网应激，并且足以诱导细胞凋亡。
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