Sweileh W M
Clinical Pharmacology, College of Pharmacy, Clinical Pharmacy Graduate Program, An-Najah National University, Nablus, Palestine.
Int J Clin Pharmacol Ther. 2007 Nov;45(11):601-5. doi: 10.5414/cpp45601.
Low-dose aspirin and diuretics are commonly co-utilized in patients with cardiovascular diseases. The objective of this study was to investigate the effects of a low-dose aspirin-diuretic drug combination on renal function.
In this cross-sectional retrospective study, all patients, excluding those on renal dialysis, admitted to the Internal Medicine Department of the Al-Watani Hospital, Nablus, Palestine, were included in the study. Medical data were obtained from patients' medical files. Estimation of creatinine clearance was carried out using the Cockcroft-Gault equation. Patients on the target drug combination were compared with patients who were not receiving the target drug combination. An independent paired t-test and 1-way ANOVA were used to test for significance between groups. Statistics were carried out using the Statistical Package for Social Sciences (SPSS), version 13.
A total of 340 subjects (54.4% men) were included in the study. There were 90 patients on the target drug combination and designated as the study group. Of the remaining 250 patients comprising the control group, 114 received none of the target drugs and 136 received only one target medication. There was a significant (p < 0.001) difference in the levels of creatinine clearance between the two groups. Patients on the target drug combination had significantly lower creatinine clearance levels than those in the control group. Men in the study group had lower creatinine clearances than men in the control group and similar results were found for women. Patients in the study group with > or = 2 chronic diseases, had lower creatinine clearances than patients in the control group with > or = 2 chronic diseases. Similar results were found in patients with < 2 chronic diseases.
Administration of a low-dose aspirin-diuretic drug combination was associated with significantly lower creatinine clearance levels. This finding was independent of gender and the number of chronic diseases present. Monitoring kidney function in patients receiving this drug combination is recommended.
低剂量阿司匹林和利尿剂常用于心血管疾病患者。本研究的目的是调查低剂量阿司匹林 - 利尿剂联合用药对肾功能的影响。
在这项横断面回顾性研究中，纳入了所有入住巴勒斯坦纳布卢斯瓦塔尼医院内科的患者，但不包括接受肾透析的患者。从患者的病历中获取医疗数据。使用Cockcroft - Gault方程估算肌酐清除率。将接受目标药物联合治疗的患者与未接受目标药物联合治疗的患者进行比较。采用独立配对t检验和单因素方差分析来检验组间差异。使用社会科学统计软件包（SPSS）13版进行统计分析。
本研究共纳入340名受试者（54.4%为男性）。有90名患者接受目标药物联合治疗并被指定为研究组。在其余构成对照组的250名患者中，114名未接受任何目标药物，136名仅接受一种目标药物。两组之间的肌酐清除率水平存在显著差异（p < 0.001）。接受目标药物联合治疗的患者肌酐清除率水平显著低于对照组。研究组中的男性肌酐清除率低于对照组中的男性，女性也有类似结果。研究组中患有≥2种慢性病的患者肌酐清除率低于对照组中患有≥2种慢性病的患者。患有<2种慢性病的患者也有类似结果。
低剂量阿司匹林 - 利尿剂联合用药与显著降低的肌酐清除率水平相关。这一发现与性别和现存慢性病数量无关。建议对接受这种药物联合治疗的患者进行肾功能监测。
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