Department of Medicine, Osun State University, Osogbo, Osun State, Nigeria ; Department of Medicine, LAUTECH Teaching Hospital, Osogbo, Osun State, Nigeria.
Int J Gen Med. 2013;6:19-24. doi: 10.2147/IJGM.S39065. Epub 2013 Jan 10.
To determine whether low dose aspirin has any deleterious effects on renal function in elderly patients.
We conducted a prospective pilot study of 30 Nigerians older than 60 years with various chronic ailments necessitating the use of low dose aspirin. Patients gave their consent, and institutional ethical clearance was obtained. Each patient's baseline samples at enrolment (before commencing aspirin use) served as a control, and subsequent weekly samples were compared. The weekly mean of each parameter was calculated, and the differences of means from baseline were determined, and values were compared for statistical differences with the Statistical Package for the Social Sciences, version 16.
We found that a majority of patients (86.67%) had basal renal functions at chronic kidney disease stages 1 and 2. When compared with the corresponding baseline parameters, the mean weekly serum and urinary electrolytes, urea, creatinine, and uric acid parameters did not change, and the P-value did not show any statistical significance. However, there was positive statistical significance for the creatinine clearance (P = 0.025). Also, unlike in previous studies, anemia and hypoalbuminemia did not affect the renal function parameters.
This study did not show any deleterious effects with short-term, low dose (75 mg daily) aspirin use on kidney functions in elderly patients. However, caution should be exercised when dealing with patients in renal stages 3-5 and the very elderly, aged ≥ 80 years.
确定小剂量阿司匹林对老年患者肾功能是否有不良影响。
我们进行了一项前瞻性的初步研究，纳入了 30 名年龄在 60 岁以上、患有各种慢性病且需要使用小剂量阿司匹林的尼日利亚人。患者同意参加，并获得了机构伦理批准。每位患者在入组时（开始使用阿司匹林之前）的基线样本作为对照，随后每周的样本进行比较。计算每周每个参数的平均值，并确定与基线的平均值差异，使用社会科学统计软件包（version 16）比较这些差异的统计学意义。
我们发现大多数患者（86.67%）的基础肾功能处于慢性肾脏病 1 期和 2 期。与相应的基线参数相比，每周血清和尿液电解质、尿素、肌酐和尿酸参数的平均值没有变化，P 值没有显示出任何统计学意义。然而，肌酐清除率有统计学意义（P = 0.025）。此外，与之前的研究不同，贫血和低白蛋白血症并不影响肾功能参数。
这项研究没有显示短期、小剂量（每天 75 毫克）阿司匹林使用对老年患者肾功能有不良影响。然而，对于处于肾 3-5 期和非常高龄（≥80 岁）的患者，应谨慎处理。
