Mallick Mamata Guha, Sengupta Sanjay, Bandyopadhyay Anjali, Chakraborty Jayati, Ray Suchandra, Guha Debasish
Department of Pathology, Bankura Sammilani Medical College, Bankura, India.
Acta Cytol. 2007 Nov-Dec;51(6):843-9. doi: 10.1159/000325858.
To throw light on cytologic findings as a possible mode of diagnosis of lymphatic filariasis.
Filariasis has worldwide distribution, but lymphatic filariasis predominantly affects tropical and subtropical regions. Demonstration of microfilaremia, the specific test for diagnosis of lymphatic filariasis, often shows false negative results in endemic areas. The present study, done in an endemic area, showed the presence of microfilariae or adult worms of Wuchereria bancrofti in fine needle aspirates collected from amicrofilariaemic cases. In a few cases the discovery was incidental. A total 4,534 cases undergoing cytologic evaluation were carefully screened for the presence of adult worms or larvae, irrespective of clinical diagnosis. Microfilariae were demonstrated in both clinically suspected cases of filariasis and asymptomatic cases.
A total of 1 positive cases were found; in 4 cases the clinical diagnosis was lymphatic filariasis, and 7 cases were asymptomatic. All 11 cases were amicrofilariaemic.
Various sophisticated investigations are used for diagnosis of lymphatic filariasis without microfilaremia. Fine needle aspiration cytology, being a cheap, simple and easy procedure, may have some role in this field, but further detailed studies are needed before any final claim.
阐明细胞学检查结果作为淋巴丝虫病一种可能诊断方式的情况。
丝虫病在全球范围内均有分布，但淋巴丝虫病主要影响热带和亚热带地区。微丝蚴血症检测作为淋巴丝虫病诊断的特异性检查，在流行地区常出现假阴性结果。本研究在一个流行地区开展，结果显示从无微丝蚴血症病例采集的细针穿刺抽吸物中存在班氏吴策线虫的微丝蚴或成虫。在少数情况下，该发现是偶然的。对总共4534例接受细胞学评估的病例进行了仔细筛查，以确定是否存在成虫或幼虫，而不考虑临床诊断。在临床疑似丝虫病病例和无症状病例中均发现了微丝蚴。
共发现11例阳性病例；其中4例临床诊断为淋巴丝虫病，7例为无症状病例。所有11例病例均无微丝蚴血症。
对于无微丝蚴血症的淋巴丝虫病诊断，采用了各种复杂的检查方法。细针穿刺抽吸细胞学检查作为一种廉价、简单且易行的方法，在该领域可能具有一定作用，但在得出最终结论之前还需要进一步详细研究。
