Afanas'ev S A, Rebrova T Iu, Kondrat'ev D S
Biomed Khim. 2007 Sep-Oct;53(5):541-6.
Changes in phospholipid composition of the erythrocyte membranes have been studied in experimental postmyocardial infarction cardiosclerosis. Erythrocyte membranes from animals with cardiosclerosis formed after experimantal occlusions of coronary arteries were characterized by significant decrease of a minor phospholipid, phosphatydylinositol (by more than 40%) and the increase of the major phospholipid, phosphatydylethanolamine. There was high content of lipid peroxidation products, malondialdehyde and conjugated dienes and the decrease in the activity of antioxidant enzymes, catalase and superoxide dismutase in blood serum of these animals. We have concluded the formation of postmyocardial infarction cardiosclerosis is accompanied by the increase of free radical reactions. This causes changes in phospholipid composition of cell membranes and the decrease of compensatory capacities of the enzymatic antioxidant system. These changes form a metabolic background, [corrected] which can influence cardiac remodelling properties.
在实验性心肌梗死后的心硬化中，对红细胞膜磷脂组成的变化进行了研究。在冠状动脉实验性闭塞后形成心硬化的动物的红细胞膜，其特征是一种次要磷脂磷脂酰肌醇显著减少（超过40%），而主要磷脂磷脂酰乙醇胺增加。这些动物血清中脂质过氧化产物丙二醛和共轭二烯含量很高，抗氧化酶过氧化氢酶和超氧化物歧化酶的活性降低。我们得出结论，心肌梗死后心硬化的形成伴随着自由基反应的增加。这导致细胞膜磷脂组成的变化以及酶促抗氧化系统代偿能力的降低。这些变化形成了一种代谢背景，可能影响心脏重塑特性。
