Schmitt D, Tran N, Riefler S, Jacoby J, Merkel D, Marone P, Naouli N
Exponent Inc, Chemical Regulation and Food Safety Practice, Wood Dale, IL 60191, USA.
Food Chem Toxicol. 2008 Mar;46(3):1048-54. doi: 10.1016/j.fct.2007.10.038. Epub 2007 Nov 5.
Modified gum acacia, produced from acacia gum by a process analogous to the production of modified food starch, was tested for mutagenicity in the microbial reverse mutation assay. The assay employed a wide range of dose levels, both with and without metabolic activation. Test results gave no indication that modified gum acacia possessed any mutagenic potential. The acute oral toxicity of modified gum acacia was determined in two studies employing Sprague-Dawley rats, and the LD50 values were found to be >2000 mg/kg. The primary dermal irritation potential of modified gum acacia was evaluated in rabbits by the Draize method. Test results indicated that modified gum acacia was slightly irritating by the Environmental Protection Agency (EPA) classification but not a primary irritant by Consumer Product Safety Commission (CPSC) guidelines. The subchronic toxicity of modified gum acacia was examined in Sprague-Dawley rats fed diets containing 0%, 1%, 2.5%, and 5% modified gum acacia for 13 weeks. No dose-related effects on survival, growth, hematology, blood chemistry, organ weights, or pathologic lesions were observed. Results of these studies indicate that modified gum acacia does not possess mutagenic potential and that animals are not adversely affected by acute or subchronic exposure to modified gum acacia.
通过类似于生产改性食品淀粉的工艺从阿拉伯胶制得的改性阿拉伯胶，在微生物回复突变试验中进行了致突变性测试。该试验采用了广泛的剂量水平，有代谢活化和无代谢活化两种情况。测试结果未表明改性阿拉伯胶具有任何致突变潜力。在两项使用斯普拉格 - 道利大鼠的研究中测定了改性阿拉伯胶的急性经口毒性，发现半数致死剂量（LD50）值>2000毫克/千克。采用德莱兹方法在兔身上评估了改性阿拉伯胶的原发性皮肤刺激性。测试结果表明，根据美国环境保护局（EPA）的分类，改性阿拉伯胶有轻微刺激性，但按照消费品安全委员会（CPSC）的指导方针不属于原发性刺激物。在喂食含0%、1%、2.5%和5%改性阿拉伯胶的饲料13周的斯普拉格 - 道利大鼠身上检查了改性阿拉伯胶的亚慢性毒性。未观察到对存活、生长、血液学、血液化学、器官重量或病理损伤有剂量相关影响。这些研究结果表明，改性阿拉伯胶不具有致突变潜力，并且动物急性或亚慢性接触改性阿拉伯胶不会受到不利影响。
