Doi Y, Ichihara T, Hagiwara A, Imai N, Tamano S, Orikoshi H, Ogasawara K, Sasaki Y, Nakamura M, Shirai T
DIMS Institute of Medical Science, Inc., 64 Goura, Nishiazai, Ichinomiya 491-0113, Japan.
Food Chem Toxicol. 2006 Apr;44(4):560-6. doi: 10.1016/j.fct.2005.09.002. Epub 2005 Oct 25.
This study was designed to evaluate and characterize any subchronic toxicity of a new type of gum arabic (SUPER GUM [Acacia(sen)SUPER GUM]), a naturally processed polysaccharide exudate from gum acacia trees (Acacia senegal), when administered to both sexes of F344 rats at dietary levels of 0 (control), 1.25%, 2.5%, and 5.0% (10 rats/sex/group). During the study, the treatment had no effects on clinical signs, survival, body weights, and food and water consumption, or on findings of urinalysis, ophthalmology, hematology, or blood biochemistry. Gross pathology and histopathology exhibited no differences of toxicological significance between control and treated rats. Increased relative cecum (filled) weights, evident in both sexes of 5.0% group and females of 1.25% and 2.5% groups, were considered to be a physiological adaptation. Thus, the results indicated the toxic level of SUPER GUM to be more than 5.0%, and the no observed adverse effect level (NOAEL) was concluded to be 5.0% (3,117 mg/kg body weights/day for males, and 3,296 mg/kg body weights/day for males) from the present study.
本研究旨在评估和表征一种新型阿拉伯胶（超级胶[阿拉伯胶（塞内加尔阿拉伯胶）超级胶]）的亚慢性毒性，该阿拉伯胶是一种从阿拉伯胶树（塞内加尔阿拉伯胶树）自然加工得到的多糖渗出物，以0（对照）、1.25%、2.5%和5.0%的饮食水平给予F344大鼠两性（每组10只大鼠/性别）。在研究期间，该处理对临床症状、存活率、体重、食物和水消耗，或尿液分析、眼科、血液学或血液生化检查结果均无影响。大体病理学和组织病理学显示，对照大鼠和处理大鼠之间没有具有毒理学意义的差异。5.0%组的两性以及1.25%和2.5%组的雌性大鼠相对盲肠（充盈）重量增加，被认为是一种生理适应。因此，结果表明超级胶的毒性水平超过5.0%，并且根据本研究得出未观察到有害作用水平（NOAEL）为5.0%（雄性为3117毫克/千克体重/天，雌性为3296毫克/千克体重/天）。
