维生素D受体基因多态性与上皮性卵巢癌风险
Vitamin D receptor polymorphisms and risk of epithelial ovarian cancer.
作者信息
Clendenen Tess V, Arslan Alan A, Koenig Karen L, Enquist Kerstin, Wirgin Isaac, Agren Asa, Lukanova Annekatrin, Sjodin Hubert, Zeleniuch-Jacquotte Anne, Shore Roy E, Hallmans Göran, Toniolo Paolo, Lundin Eva
机构信息
Department of Environmental Medicine, New York University School of Medicine, New York, NY 10016, USA.
出版信息
Cancer Lett. 2008 Feb 18;260(1-2):209-15. doi: 10.1016/j.canlet.2007.11.002.
Abstract
The vitamin D receptor (VDR) is a critical mediator of the cellular effects of vitamin D. The associations between four common VDR polymorphisms (BSMI, APAI, TAQI, and FOKI) and risk of epithelial ovarian cancer (EOC) were assessed in a case-control study nested within two prospective cohorts. One hundred seventy incident cases of EOC and 323 individually matched controls were genotyped. Overall, no associations were observed in genotype analyses. Haplotypes combining three SNPs in high linkage disequilibrium (BSMI, APAI, and TAQI) were also not associated with risk. These observations do not support a role for BSMI, APAI, TAQI, and FOKI polymorphisms in epithelial ovarian cancer in a predominantly Caucasian population.
摘要
维生素D受体（VDR）是维生素D细胞效应的关键介质。在两项前瞻性队列研究中的一项病例对照研究中，评估了四种常见的VDR基因多态性（BSMI、APAI、TAQI和FOKI）与上皮性卵巢癌（EOC）风险之间的关联。对170例EOC新发病例和323例个体匹配对照进行了基因分型。总体而言，在基因型分析中未观察到关联。处于高度连锁不平衡状态的三个单核苷酸多态性（BSMI、APAI和TAQI）组合的单倍型也与风险无关。这些观察结果不支持在以白种人为主的人群中，BSMI、APAI、TAQI和FOKI基因多态性在上皮性卵巢癌中起作用。
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