Department of Geriatrics, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, PR China.
Department of Nephrology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, PR China.
Arch Med Res. 2015 Jan;46(1):1-7. doi: 10.1016/j.arcmed.2014.11.017. Epub 2014 Nov 27.
To evaluate the association between vitamin D receptor (VDR) BsmI, FokI, TaqI and ApaI gene polymorphisms and the risk of end-stage renal disease (ESRD).
All eligible studies were included in our meta-analysis of a search of the PubMed, Cochrane and China National Knowledge Infrastructure (CNKI) databases according to predefined criteria. The fixed-effects or random-effects models were used to calculate the pooled odds ratio (OR) and corresponding 95% confidence interval (CI).
Thirteen studies including 1510 patients and 1812 controls were recruited for the analysis of the association between the VDR BsmI, FokI, TaqI and ApaI gene polymorphisms and the risk of ESRD.VDR BsmI B allele, BB genotype and bb genotype, FokI F allele, FF genotype and ff genotype, TaqI T allele, TT genotype and tt genotype, ApaI A allele, AA genotype and aa genotype were not associated with ESRD susceptibility for overall populations, Asians and Caucasians.
Results from the current study suggest that VDR BsmI, FokI, TaqI and ApaI gene polymorphisms are not associated with the risk of ESRD in the overall populations, Asians and Caucasians. However, more studies should be performed in the future.
评估维生素 D 受体（VDR）BsmI、FokI、TaqI 和 ApaI 基因多态性与终末期肾病（ESRD）风险之间的关联。
根据预设标准，我们对 PubMed、Cochrane 和中国国家知识基础设施（CNKI）数据库进行了搜索，将所有符合条件的研究纳入我们的荟萃分析。使用固定效应或随机效应模型计算合并的优势比（OR）和相应的 95％置信区间（CI）。
纳入了 13 项研究，共包括 1510 名患者和 1812 名对照，用于分析 VDR BsmI、FokI、TaqI 和 ApaI 基因多态性与 ESRD 风险之间的关联。VDR BsmI B 等位基因、BB 基因型和 bb 基因型、FokI F 等位基因、FF 基因型和 ff 基因型、TaqI T 等位基因、TT 基因型和 tt 基因型、ApaI A 等位基因、AA 基因型和 aa 基因型与总体人群、亚洲人和高加索人患 ESRD 的易感性无关。
本研究结果表明，VDR BsmI、FokI、TaqI 和 ApaI 基因多态性与总体人群、亚洲人和高加索人患 ESRD 的风险无关。但是，未来需要进行更多的研究。
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