Dettling A, Skopp G, Graw M, Haffner H-Th
Institute of Forensic Medicine and Traffic Medicine, University of Heidelberg, 69115 Heidelberg, Germany.
Forensic Sci Int. 2008 May 20;177(2-3):85-9. doi: 10.1016/j.forsciint.2007.11.002. Epub 2008 Feb 20.
The goal of the investigation was to research the influence of sex hormones on the elimination kinetics of ethanol. Forty-seven healthy men (average age 25+/-6.1 years) and 61 healthy women (average age 24+/-2.4 years) received 0.79-0.95g of ethanol/kg body weight in the form of an alcohol beverage of their choice. The target concentration for both sexes was a blood alcohol concentration (BAC) of 1.10g/kg. Blood samples for the determination of the ethanol concentration followed in the elimination phase in 10-20min intervals. The sex hormone levels (estradiol, progesterone and testosterone) were determined concomitantly from the serum. In men, the mean testosterone concentration was 5.3+/-1.6ng/ml, the mean estradiol concentration was 34.6+/-13.6pg/ml and the mean progesterone concentration was 0.9+/-0.3ng/ml. In women, the mean estradiol concentration was 47.6+/-52.6pg/ml and the mean testosterone concentration was 0.8+/-0.4ng/ml. Progesterone displayed a so-called dummy effect in women. In the high progesterone group (n=11), the mean concentration was 11.1+/-3.5ng/ml and in the low progesterone group (n=50) the mean was 0.6+/-0.3ng/ml. The mean hourly elimination rate (beta60) was 0.1677+/-0.0311g/kg/h in men. In women, the mean hourly elimination rate was 0.2044+/-0.0414g/kg/h in the high progesterone group and 0.1850+/-0.0276g/kg/h in the low progesterone group (p<0.05). The beta60 for women in the low progesterone group was significantly higher than that of the men, whose progesterone levels fell within a similar range (p>0.01). These results allow one to conclude that the gender differences in the pharmacokinetics of ethanol can partly, but not completely, be explained by progesterone levels.
该研究的目的是探究性激素对乙醇消除动力学的影响。47名健康男性（平均年龄25±6.1岁）和61名健康女性（平均年龄24±2.4岁）以他们选择的酒精饮料形式摄入0.79 - 0.95克乙醇/千克体重。两性的目标浓度均为血液酒精浓度（BAC）1.10克/千克。在消除阶段，每隔10 - 20分钟采集血样以测定乙醇浓度。同时从血清中测定性激素水平（雌二醇、孕酮和睾酮）。男性中，睾酮平均浓度为5.3±1.6纳克/毫升，雌二醇平均浓度为34.6±13.6皮克/毫升，孕酮平均浓度为0.9±0.3纳克/毫升。女性中，雌二醇平均浓度为47.6±52.6皮克/毫升，睾酮平均浓度为0.8±0.4纳克/毫升。孕酮在女性中呈现出所谓的虚拟效应。在高孕酮组（n = 11）中，平均浓度为11.1±3.5纳克/毫升，在低孕酮组（n = 50）中平均浓度为0.6±0.3纳克/毫升。男性的平均每小时消除率（β60）为0.1677±0.0311克/千克/小时。在女性中，高孕酮组的平均每小时消除率为0.2044±0.0414克/千克/小时，低孕酮组为0.1850±0.0276克/千克/小时（p<0.05）。低孕酮组女性的β60显著高于孕酮水平处于相似范围（p>0.01）的男性。这些结果使人们能够得出结论，乙醇药代动力学中的性别差异可以部分但不能完全由孕酮水平来解释。
