Ye Yi, Lin Yidie, Haseba Takeshi, Chen Fan, Cui Fanlai, Yi Xiaoqin, Fan Weihao, Li Gangqin
Department of Forensic Toxicological Analysis, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, China.
Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Ann Med. 2025 Dec;57(1):2496798. doi: 10.1080/07853890.2025.2496798. Epub 2025 Apr 28.
Psychomotor impairments due to alcohol consumption may lead to a series of negative consequences. However, the influence of sex and polymorphism on psychomotor dysfunction has not yet been investigated.
One-hundred and three participants, genotyped for rs671, were administered a dose of 1.0 g/kg of white spirits. The blood ethanol concentration (BEC) and acetaldehyde concentration (BAAC) were measured at specific time intervals before and after alcohol consumption. Additionally, auditory simple reaction time (ASRT), visual choice reaction time (VCRT), pursuit tracking task (PTT) and digit-symbol substitution test (DSST) were used to evaluate psychomotor function. Linear mixed-effects model was used to analyze the effects of sex and the genotype on alcohol metabolism and psychomotor function..
Acetaldehyde metabolism depended on both genotype and sex. Women with genotype exhibited 2.21 to 18.27 µmol/L higher BAAC levels than men with the same genotype. Conversely, among participants with genotype, BAAC levels of women were 0.25 to 31.32 µmol/L lower than men. The impact of genotype on psychomotor function varied across the four tests. VCRT increased significantly in men with genotype compared to those with at 2-4 h post-consumption. In the PTT test, the percentage of time on target decreased by 3.83% and 3.11% in women relative to men at 1 and 2 h post-consumption, respectively. Notably, ASRT performance was significantly correlated with BAAC levels. No effects of genotype and sex were observed on DSST performance.
genotype and sex independently or interactively contribute to alcohol-related psychomotor impairment.
饮酒导致的精神运动功能障碍可能会引发一系列负面后果。然而，性别和基因多态性对精神运动功能障碍的影响尚未得到研究。
对103名进行了rs671基因分型的参与者给予1.0 g/kg的白酒剂量。在饮酒前后的特定时间间隔测量血液乙醇浓度（BEC）和乙醛浓度（BAAC）。此外，使用听觉简单反应时（ASRT）、视觉选择反应时（VCRT）、追踪追踪任务（PTT）和数字符号替换测试（DSST）来评估精神运动功能。采用线性混合效应模型分析性别和基因型对酒精代谢及精神运动功能的影响。
乙醛代谢取决于基因型和性别。具有该基因型的女性比具有相同基因型的男性BAAC水平高2.21至18.27 μmol/L。相反，在具有该基因型的参与者中，女性的BAAC水平比男性低0.25至31.32 μmol/L。基因型对精神运动功能的影响在四项测试中各不相同。与具有该基因型的男性相比，饮酒后2至4小时，具有该基因型的男性VCRT显著增加。在PTT测试中，饮酒后1小时和2小时，女性相对于男性在目标上花费时间的百分比分别下降了3.83%和3.11%。值得注意的是，ASRT表现与BAAC水平显著相关。未观察到基因型和性别对DSST表现有影响。
基因型和性别独立或交互作用导致与酒精相关的精神运动功能损害。
