Fischl Bruce, Rajendran Niranjini, Busa Evelina, Augustinack Jean, Hinds Oliver, Yeo B T Thomas, Mohlberg Hartmut, Amunts Katrin, Zilles Karl
Department of Radiology, Harvard Medical School, Charlestown, MA 02129, USA.
Cereb Cortex. 2008 Aug;18(8):1973-80. doi: 10.1093/cercor/bhm225. Epub 2007 Dec 12.
The human cerebral cortex is made up of a mosaic of structural areas, frequently referred to as Brodmann areas (BAs). Despite the widespread use of cortical folding patterns to perform ad hoc estimations of the locations of the BAs, little is understood regarding 1) how variable the position of a given BA is with respect to the folds, 2) whether the location of some BAs is more variable than others, and 3) whether the variability is related to the level of a BA in a putative cortical hierarchy. We use whole-brain histology of 10 postmortem human brains and surface-based analysis to test how well the folds predict the locations of the BAs. We show that higher order cortical areas exhibit more variability than primary and secondary areas and that the folds are much better predictors of the BAs than had been previously thought. These results further highlight the significance of cortical folding patterns and suggest a common mechanism for the development of the folds and the cytoarchitectonic fields.
人类大脑皮层由一系列结构区域组成，这些区域常被称为布罗德曼区（BAs）。尽管广泛使用皮质折叠模式来临时估计布罗德曼区的位置，但对于以下几点我们知之甚少：1）给定布罗德曼区的位置相对于褶皱的变化程度如何；2）某些布罗德曼区的位置是否比其他区域更具变化性；3）这种变化性是否与假定的皮质层级中布罗德曼区的层级水平相关。我们使用10个死后人类大脑的全脑组织学和基于表面的分析来测试褶皱对布罗德曼区位置的预测能力有多强。我们发现，高阶皮质区域比初级和次级区域表现出更大的变化性，并且褶皱对布罗德曼区的预测能力比之前认为的要好得多。这些结果进一步凸显了皮质折叠模式的重要性，并暗示了褶皱和细胞构筑区域发育的共同机制。
