Ercan Tugba Erener, Ercan Gokmen, Severge Burcu, Arpaozu Muhsin, Karasu Gulten
Maltepe University Medical Faculty, Department of Pediatrics, Ataturk Cad. Cam Sok. No 3, Maltepe, Istanbul, Turkey.
J Child Neurol. 2008 Mar;23(3):338-40. doi: 10.1177/0883073807308714. Epub 2007 Dec 13.
It has been demonstrated that obsessive-compulsive disease and/or tic syndromes in children may be triggered by an antecedent infection especially with group A beta-hemolytic streptococci, and this subgroup of children has been designated by the acronym PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections). Other infectious agents such as viruses and bacteria have also been reported to be associated with the acute onset or dramatic exacerbation of obsessive-compulsive disease or Tourette syndrome, and another acronym, PITAND (pediatric infection-triggered autoimmune neuropsychiatric disorder) has appeared in the literature. The involvement of other infectious agents such as Mycoplasma pneumoniae has been described in single case reports. We describe a case of a 5.5-year-old boy who suddenly developed obsessive-compulsive disease symptoms during a M. pneumoniae pneumonia. After treatment with oral clarithromycin, all his obsessive-compulsive disease symptoms disappeared. To our knowledge, this is the first report that shows the association between Mycoplasma pneumoniae infection and obsessive-compulsive disease.
已证实，儿童的强迫症和/或抽动综合征可能由先前的感染引发，尤其是A组β溶血性链球菌感染，这类儿童亚组已被简称为PANDAS（与链球菌感染相关的儿童自身免疫性神经精神疾病）。据报道，其他感染因子如病毒和细菌也与强迫症或抽动秽语综合征的急性发作或显著加重有关，文献中还出现了另一个首字母缩写词PITAND（儿童感染引发的自身免疫性神经精神疾病）。在个别病例报告中描述了其他感染因子如肺炎支原体的参与情况。我们描述了一名5.5岁男孩的病例，他在患肺炎支原体肺炎期间突然出现强迫症症状。口服克拉霉素治疗后，他所有的强迫症症状都消失了。据我们所知，这是第一份显示肺炎支原体感染与强迫症之间关联的报告。
