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恶唑烷二酮衍生的比卡鲁胺类似物的合成。

Synthesis of oxazolidinedione derived bicalutamide analogs.

作者信息

Nair Vipin A, Mustafa Suni M, Mohler Michael L, Dalton James T, Miller Duane D

机构信息

Department of Pharmaceutical Sciences, University of Tennessee, 847 Monroe Avenue, RM 227 C, Memphis, TN 38163, USA.

出版信息

Tetrahedron Lett. 2006 Jun 5;47(23):3953-3955. doi: 10.1016/j.tetlet.2006.03.146.

DOI:10.1016/j.tetlet.2006.03.146
PMID:18079987
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2134919/
Abstract

The synthesis of chiral oxazolidinedione derived bicalutamide analogs has been discussed.

摘要

已对源自比卡鲁胺的手性恶唑烷二酮类似物的合成进行了讨论。

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本文引用的文献

1
Synthesis of irreversibly binding bicalutamide analogs for imaging studies.用于成像研究的不可逆结合比卡鲁胺类似物的合成。
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2
Structural basis for antagonism and resistance of bicalutamide in prostate cancer.比卡鲁胺在前列腺癌中拮抗作用和耐药性的结构基础
Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6201-6. doi: 10.1073/pnas.0500381102. Epub 2005 Apr 15.
3
A selective androgen receptor modulator for hormonal male contraception.一种用于激素男性避孕的选择性雄激素受体调节剂。
J Pharmacol Exp Ther. 2005 Feb;312(2):546-53. doi: 10.1124/jpet.104.075424. Epub 2004 Sep 3.
4
Comparison of the pharmacological effects of a novel selective androgen receptor modulator, the 5alpha-reductase inhibitor finasteride, and the antiandrogen hydroxyflutamide in intact rats: new approach for benign prostate hyperplasia.新型选择性雄激素受体调节剂、5α-还原酶抑制剂非那雄胺及抗雄激素药物羟基氟他胺在成年大鼠体内的药理作用比较：良性前列腺增生的新研究方法
Endocrinology. 2004 Dec;145(12):5420-8. doi: 10.1210/en.2004-0627. Epub 2004 Aug 12.
5
A ligand-based approach to identify quantitative structure-activity relationships for the androgen receptor.一种基于配体的方法来确定雄激素受体的定量构效关系。
J Med Chem. 2004 Jul 15;47(15):3765-76. doi: 10.1021/jm0499007.
6
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