Parot Pierre, Dufrêne Yves F, Hinterdorfer Peter, Le Grimellec Christian, Navajas Daniel, Pellequer Jean-Luc, Scheuring Simon
CEA-Valrhô DSV/iBEB/SBTN, 30207 Bagnols sur Cèze Marcoule, France.
J Mol Recognit. 2007 Nov-Dec;20(6):418-31. doi: 10.1002/jmr.857.
To introduce this special issue of the Journal of Molecular Recognition dedicated to the applications of atomic force microscopy (AFM) in life sciences, this paper presents a short summary of the history of AFM in biology. Based on contributions from the first international conference of AFM in biological sciences and medicine (AFM BioMed Barcelona, 19-21 April 2007), we present and discuss recent progress made using AFM for studying cells and cellular interactions, probing single molecules, imaging biosurfaces at high resolution and investigating model membranes and their interactions. Future prospects in these different fields are also highlighted.
为介绍《分子识别杂志》的这一关于原子力显微镜（AFM）在生命科学中应用的特刊，本文简要概述了AFM在生物学领域的发展历程。基于首届生物科学与医学AFM国际会议（2007年4月19 - 21日，巴塞罗那AFM生物医学会议）的成果，我们展示并讨论了利用AFM在研究细胞及细胞间相互作用、探测单分子、高分辨率成像生物表面以及研究模型膜及其相互作用等方面取得的最新进展。同时也强调了这些不同领域的未来前景。
