Avunduk Sibel, Mitaine-Offer Anne-Claire, Alankuş-Calişkan Ozgen, Miyamoto Tomofumi, Senol Serdar Gökhan, Lacaille-Dubois Marie-Aleth
Department of Chemistry, Faculty of Sciences, Ege University 2, Bornova, Izmir, Turkey.
J Nat Prod. 2008 Jan;71(1):141-5. doi: 10.1021/np0703500. Epub 2007 Dec 15.
Six new triterpene saponins, 3-O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-xylopyranosyl-(1-->2)-beta-D-glucuronopyranosyl-21-epi-kudzusapogenol A (1), 3-O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyranosyl-(1-->2)-beta-D-glucuronopyranosyl-21-epi-kudzusapogenol A (2), 3-O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-xylopyranosyl-(1-->2)-beta-D-glucuronopyranosyl-22-O-beta-D-glucopyranosyl-21-epi-kudzusapogenol A (3), 3-O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyranosyl-(1-->2)-beta-D-glucuronopyranosyl-22-O-beta-D-glucopyranosyl-21-epi-kudzusapogenol A (4), 3-O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-xylopyranosyl-(1-->2)-beta-D-glucuronopyranosyl-22-O-alpha-L-arabinopyranosyl-21-epi-kudzusapogenol A (5), and 3-O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyranosyl-(1-->2)-beta-D-glucuronopyranosyl-22-O-alpha-L-arabinopyranosyl-21-epi-kudzusapogenol A (6), were isolated from the roots of Astragalus flavescens, together with the known trajanoside B, azukisaponin V, and astragalosides IV, VII, and VIII. Their structures were established mainly by 2D NMR techniques and mass spectrometry.
从淡黄耆根部分离得到6个新的三萜皂苷，分别为3 - O - α - L - 鼠李吡喃糖基 - (1→2) - β - D - 木吡喃糖基 - (1→2) - β - D - 葡糖醛酸吡喃糖基 - 21 - 表 - 葛根皂苷元A（1）、3 - O - α - L - 鼠李吡喃糖基 - (1→2) - β - D - 葡萄糖吡喃糖基 - (1→2) - β - D - 葡糖醛酸吡喃糖基 - 21 - 表 - 葛根皂苷元A（2）、3 - O - α - L - 鼠李吡喃糖基 - (1→2) - β - D - 木吡喃糖基 - (1→2) - β - D - 葡糖醛酸吡喃糖基 - 22 - O - β - D - 葡萄糖吡喃糖基 - 21 - 表 - 葛根皂苷元A（3）、3 - O - α - L - 鼠李吡喃糖基 - (1→2) - β - D - 葡萄糖吡喃糖基 - (1→2) - β - D - 葡糖醛酸吡喃糖基 - 22 - O - β - D - 葡萄糖吡喃糖基 - 21 - 表 - 葛根皂苷元A（4）、3 - O - α - L - 鼠李吡喃糖基 - (1→2) - β - D - 木吡喃糖基 - (1→2) - β - D - 葡糖醛酸吡喃糖基 - 22 - O - α - L - 阿拉伯吡喃糖基 - 21 - 表 - 葛根皂苷元A（5）和3 - O - α - L - 鼠李吡喃糖基 - (1→2) - β - D - 葡萄糖吡喃糖基 - (1→2) - β - D - 葡糖醛酸吡喃糖基 - 22 - O - α - L - 阿拉伯吡喃糖基 - 21 - 表 - 葛根皂苷元A（6），同时还得到了已知的trajanoside B、赤小豆皂苷V以及黄芪皂苷IV、VII和VIII。它们的结构主要通过二维核磁共振技术和质谱得以确定。
