黄芪属植物中的三萜皂苷。

Triterpenoid saponins from Astragalus wiedemannianus Fischer.

机构信息

Ege University, Faculty of Science, Department of Chemistry, Bornova, Izmir, Turkey.

出版信息

Phytochemistry. 2010 Apr;71(5-6):658-62. doi: 10.1016/j.phytochem.2009.11.013. Epub 2010 Jan 12.

DOI:10.1016/j.phytochem.2009.11.013

PMID:20060986

Abstract

Three cycloartane-type triterpene glycosides were isolated from Astragalus wiedemannianus together with eight known secondary metabolites namely cycloastragenol, cycloascauloside B, astragaloside IV, astragaloside VIII, brachyoside B, astragaloside II, astrachrysoside A, and astrasieversianin X. The structures were established mainly by a combination of 1D and 2D-NMR techniques as 3-O-[alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyranosyl]-25-O-beta-D-glucopyranosyl-20(R),24(S)-epoxy-3beta,6alpha,16beta,25-tetrahydroxycycloartane, 3-O-[alpha-L-rhamnopyranosyl-(1-->2)-beta-D-xylopyranosyl]-6-O-beta-D-glucopyranosyl-24-O-alpha-(4'-O-acetoxy)-L-arabinopyranosyl-16-O-acetoxy-3beta,6alpha,16beta,24(S),25-pentahydroxycycloartane, 3-O-[alpha-L-rhamnopyranosyl-(1-->2)-beta-D-xylopyranosyl]-6-O-beta-D-glucopyranosyl-24-O-alpha-L-arabinopyranosyl-16-O-acetoxy-3beta,6alpha,16beta,24(S),25-pentahydroxycycloartane. To the best of our knowledge, the presence of an arabinose moiety on the acyclic side chain of cycloartanes is reported for the first time.

摘要

从黄芪中分离得到三种环阿尔廷型三萜糖苷，以及八种已知的次生代谢产物，即环黄芪醇、环葫芦素 B、黄芪甲苷 IV、黄芪甲苷 VIII、远志糖苷 B、黄芪甲苷 II、astrasieversianin A 和 astrasieversianin X。结构主要通过 1D 和 2D-NMR 技术的组合确定，分别为 3-O-[alpha-L-鼠李吡喃糖基-(1-->2)-beta-D-吡喃葡萄糖基]-25-O-beta-D-吡喃葡萄糖基-20(R),24(S)-环氧-3beta,6alpha,16beta,25-四羟基环阿尔廷烷、3-O-[alpha-L-鼠李吡喃糖基-(1-->2)-beta-D-木吡喃糖基]-6-O-beta-D-吡喃葡萄糖基-24-O-alpha-(4'-O-乙酰氧基)-L-阿拉伯吡喃糖基-16-O-乙酰氧基-3beta,6alpha,16beta,24(S),25-五羟基环阿尔廷烷、3-O-[alpha-L-鼠李吡喃糖基-(1-->2)-beta-D-木吡喃糖基]-6-O-beta-D-吡喃葡萄糖基-24-O-alpha-L-阿拉伯吡喃糖基-16-O-乙酰氧基-3beta,6alpha,16beta,24(S),25-五羟基环阿尔廷烷。据我们所知，这是首次在环阿尔廷烷的非环侧链上存在阿拉伯糖部分。