苦丁茶冬青叶中的三萜皂苷
Triterpene saponins from the leaves of Ilex kudingcha.
作者信息
Tang Li, Jiang Yong, Chang Hai-Tao, Zhao Ming-Bo, Tu Peng-Fei, Cui Jing-Rong, Wang Rui-Qing
机构信息
School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100083, People's Republic of China.
出版信息
J Nat Prod. 2005 Aug;68(8):1169-74. doi: 10.1021/np050043z.
Nine new triterpene saponins, ilekudinosides K-S (1-9), and eight known triterpene saponins were isolated from the 70% ethanol extract of the leaves of Ilex kudingcha. The new saponins were characterized as 3-O-alpha-L-rhamnopyranosyl(1-->2)-beta-D-glucopyranosyl-alpha-kudinlactone (1), 3-O-beta-D-glucopyranosyl(1-->3)-alpha-L-arabinopyranosyl-beta-kudinlactone (2), 3-O-alpha-L-rhamnopyranosyl(1-->2)-alpha-L-arabinopyranosyl-gamma-kudinlactone (3), 3-O-beta-D-glucopyranosyl(1-->2)-beta-D-glucopyranosyl-alpha-kudinlactone (4), 3-O-beta-D-glucopyranosyl(1-->2)-alpha-L-arabinopyranosyl-alpha-kudinlactone (5), 3-O-beta-D-glucopyranosyl(1-->3)-alpha-L-arabinopyranosyl-alpha-kudinlactone (6), 3-O-alpha-L-rhamnopyranosyl(1-->2)-beta-D-glucopyranosyl-beta-kudinlactone (7), 3-O-alpha-L-rhamnopyranosyl(1-->2)-alpha-L-arabinopyranosyl-beta-kudinlactone (8), and 3-O-alpha-L-rhamnopyranosyl(1-->2)-beta-D-glucopyranosyl-gamma-kudinlactone (9), respectively. The structures and stereochemistry of compounds 1-9 were elucidated by spectroscopic data interpretation and chemical degradation.
从苦丁茶冬青叶的70%乙醇提取物中分离得到9个新的三萜皂苷，即苦丁茶苷K - S（1 - 9），以及8个已知的三萜皂苷。新皂苷分别被鉴定为3 - O-α-L-鼠李吡喃糖基（1→2）-β-D-葡萄糖吡喃糖基-α-苦丁内酯（1）、3 - O-β-D-葡萄糖吡喃糖基（1→3）-α-L-阿拉伯吡喃糖基-β-苦丁内酯（2）、3 - O-α-L-鼠李吡喃糖基（1→2）-α-L-阿拉伯吡喃糖基-γ-苦丁内酯（3）、3 - O-β-D-葡萄糖吡喃糖基（1→2）-β-D-葡萄糖吡喃糖基-α-苦丁内酯（4）、3 - O-β-D-葡萄糖吡喃糖基（1→2）-α-L-阿拉伯吡喃糖基-α-苦丁内酯（5）、3 - O-β-D-葡萄糖吡喃糖基（1→3）-α-L-阿拉伯吡喃糖基-α-苦丁内酯（6）、3 - O-α-L-鼠李吡喃糖基（1→2）-β-D-葡萄糖吡喃糖基-β-苦丁内酯（7）、3 - O-α-L-鼠李吡喃糖基（1→2）-α-L-阿拉伯吡喃糖基-β-苦丁内酯（8）和3 - O-α-L-鼠李吡喃糖基（1→2）-β-D-葡萄糖吡喃糖基-γ-苦丁内酯（9）。通过光谱数据解析和化学降解对化合物1 - 9的结构和立体化学进行了阐明。
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