Kubota Yasutaka, Toichi Motomi, Shimizu Mitsue, Mason Richard A, Findling Robert L, Yamamoto Kokichi, Calabrese Joseph R
Mood Disorders Program, Department of Psychiatry, Case Western Reserve University/University Hospitals of Cleveland, Cleveland, OH 44106, USA.
Neuroimage. 2006 Jul 15;31(4):1783-9. doi: 10.1016/j.neuroimage.2006.02.003. Epub 2006 Mar 20.
Evidence from lesion studies suggests an important role of the prefrontal cortex (PFC) in the reconstructive processes of episodic memory or memory distortion. Results from functional imaging studies imply PFC involvement during the illusionary recollection of non-experienced events. Here, we used a two-channel near-infrared spectroscopy (NIRS) system and conducted real-time monitoring of PFC hemodynamics, while subjects studied word lists and subsequently recognized unstudied items (false recognition). Bilateral increases in the oxygenated hemoglobin concentration ([oxy-Hb]) were observed during false recognition compared to true recognition, and a left PFC dominant increase of [oxy-Hb] was observed during encoding phases where subjects later claimed that they recognized unstudied words. Traces of semantic processing, reflected primarily in the left PFC activity, could eventually predict whether subjects falsely recognize non-experienced events.
来自损伤研究的证据表明，前额叶皮层（PFC）在情景记忆或记忆扭曲的重建过程中起着重要作用。功能成像研究的结果表明，PFC在对未经历事件的虚幻回忆过程中发挥作用。在这里，我们使用双通道近红外光谱（NIRS）系统，对PFC的血液动力学进行实时监测，同时让受试者学习单词列表，随后识别未学习的项目（错误识别）。与正确识别相比，在错误识别过程中观察到双侧氧合血红蛋白浓度（[oxy-Hb]）增加，并且在编码阶段观察到左PFC的[oxy-Hb]主要增加，在该阶段受试者后来声称他们识别出了未学习的单词。主要反映在左PFC活动中的语义处理痕迹最终可以预测受试者是否会错误识别未经历的事件。
