Sumitani Satsuki, Tanaka Tsunehiko, Tayoshi Shin'Ya, Ota Koshi, Kameoka Naomi, Ueno Shu-ichi, Ohmori Tetsuro
Department of Psychiatry, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan.
Neuropsychobiology. 2006;53(2):70-6. doi: 10.1159/000091722. Epub 2006 Feb 23.
The Wisconsin Card Sorting Test (WCST) is a neuropsychological test to evaluate the function of the prefrontal cortex (PFC). However, inconsistent results have been reported concerning whether this task activates the PFC symmetrically or asymmetrically.
To investigate the brain activation in the PFC during the WCST, we examined blood oxygenation changes of healthy subjects by using multichannel near-infrared spectroscopy (NIRS).
Subjects were 32 healthy volunteers, 18 males and 14 females. The WCST was administered using a computerized version, and the hemodynamic changes of the PFC during the WCST were measured by a 24-channel NIRS system.
A bilateral increase in oxygenated hemoglobin (oxyHb) was observed in the PFC in 20 subjects during the WCST. However, 5 subjects showed predominant activation on the left side and 3 subjects one on the right side. No oxyHb change was observed in 4 subjects, although they had good performances in the WCST.
These results directly confirmed that the PFC was activated during the WCST in vivo by using the optical technique and suggested that the distribution of the activation in the PFC is different among healthy individuals.
威斯康星卡片分类测验（WCST）是一种用于评估前额叶皮质（PFC）功能的神经心理学测验。然而，关于该任务激活PFC是对称还是不对称，已有不一致的结果报道。
为了研究WCST期间PFC的脑激活情况，我们使用多通道近红外光谱（NIRS）检查了健康受试者的血液氧合变化。
受试者为32名健康志愿者（18名男性和14名女性）。使用计算机化版本进行WCST，并通过24通道NIRS系统测量WCST期间PFC的血流动力学变化。
20名受试者在WCST期间PFC中观察到双侧氧合血红蛋白（oxyHb）增加。然而，5名受试者表现为左侧优势激活，3名受试者表现为右侧优势激活。4名受试者在WCST中表现良好，但未观察到oxyHb变化。
这些结果直接证实了使用光学技术在体内WCST期间PFC被激活，并表明健康个体中PFC激活的分布有所不同。
